Beta-ureidopropionase explained

beta-ureidopropionase
Ec Number:	3.5.1.6
Cas Number:	9027-27-4
Go Code:	0003837

In enzymology, a beta-ureidopropionase is an enzyme that catalyzes the chemical reaction

N-carbamoyl-beta-alanine + H₂O

\rightleftharpoons beta-alanine + CO₂ + NH₃

Thus, the two substrates of this enzyme are N-carbamoyl-beta-alanine and H₂O, whereas its 3 products are beta-alanine, CO₂, and NH₃.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is N-carbamoyl-beta-alanine amidohydrolase. This enzyme participates in 3 metabolic pathways: pyrimidine metabolism, beta-alanine metabolism, and pantothenate and coenzyme A biosynthesis.

Structural studies

As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes,,,,, and .

References

• CAMPBELL LL . 1960 . Reductive degradation of pyrimidines. 5. Enzymatic conversion of N-carbamyl-beta-alanine to beta-alanine, carbon dioxide, and ammonia . J. Biol. Chem. . 235 . 2375 - 8 . 10.1016/S0021-9258(18)64630-7 . free . 13849303 .
• CARAVACA J, GRISOLIA S . 1958 . Enzymatic decarbamylation of carbamyl beta-alanine and carbamyl beta-aminoisobutyric acid . J. Biol. Chem. . 231 . 357 - 65 . 13538975 . 1 . 10.1016/S0021-9258(19)77312-8 . free .
• Traut TW, Loechel S . 1984 . Pyrimidine catabolism: individual characterization of the three sequential enzymes with a new assay . Biochemistry . 23 . 2533 - 9 . 6433973 . 10.1021/bi00306a033 . 11 .