Beta-peptidyl aminopeptidase explained

Beta-peptidyl aminopeptidase
Ec Number:	3.4.11.25

Beta-peptidyl aminopeptidase (BapA) is an enzyme.^{[1] [2] [3] [4]} This enzyme catalyses the following chemical reaction:

Cleaves N-terminal beta-homoamino acids from peptides composed of 2 to 6 amino acids

Sphingosinicella xenopeptidilytica strain 3-2W4 could use beta-peptides beta-homoVal-beta-homoAla-beta-homoLeu and beta-homoAla-beta-homoLeu as only source of carbon and energy.

Notes and References

1. Heck T, Limbach M, Geueke B, Zacharias M, Gardiner J, Kohler HP, Seebach D . Enzymatic degradation of beta- and mixed alpha,beta-oligopeptides . Chemistry & Biodiversity . 3 . 12 . 1325–48 . December 2006 . 17193247 . 10.1002/cbdv.200690136 . 38292191 .
2. Geueke B, Namoto K, Seebach D, Kohler HP . A novel beta-peptidyl aminopeptidase (BapA) from strain 3-2W4 cleaves peptide bonds of synthetic beta-tri- and beta-dipeptides . Journal of Bacteriology . 187 . 17 . 5910–7 . September 2005 . 16109932 . 1196161 . 10.1128/jb.187.17.5910-5917.2005 .
3. Geueke B, Heck T, Limbach M, Nesatyy V, Seebach D, Kohler HP . Bacterial beta-peptidyl aminopeptidases with unique substrate specificities for beta-oligopeptides and mixed beta,alpha-oligopeptides . The FEBS Journal . 273 . 23 . 5261–72 . December 2006 . 17064315 . 10.1111/j.1742-4658.2006.05519.x . 84167461 . free .
4. Heck T, Kohler HP, Limbach M, Flögel O, Seebach D, Geueke B . Enzyme-catalyzed formation of beta-peptides: beta-peptidyl aminopeptidases BapA and DmpA acting as beta-peptide-synthesizing enzymes . Chemistry & Biodiversity . 4 . 9 . 2016–30 . September 2007 . 17886858 . 10.1002/cbdv.200790168 . 85123861 .