Β-Mannosidase Explained

β-Mannosidase
Ec Number:	3.2.1.25
Cas Number:	9025-43-8
Go Code:	0004567

β-Mannosidase (}, mannanase, mannase, β-D-mannosidase, β-mannoside mannohydrolase, exo-β-D-mannanase, lysosomal β A mannosidase) is an enzyme with systematic name β-D-mannoside mannohydrolase, which is in humans encoded by the MANBA gene.^{[1] [2] [3] [4] [5] [6]} This enzyme catalyses the following chemical reaction

Hydrolysis of terminal, non-reducing β-D-mannose residues in β-D-mannosides

This gene encodes a member of the glycosyl hydrolase 2 family. The encoded protein localizes to the lysosome where it is the final exoglycosidase in the pathway for N-linked glycoprotein oligosaccharide catabolism. Mutations in this gene are associated with β-mannosidosis, a lysosomal storage disease that has a wide spectrum of neurological involvement.^[1]

Further reading

• Bolmstedt A, Sjölander S, Hansen JE . Influence of N-linked glycans in V4-V5 region of human immunodeficiency virus type 1 glycoprotein gp160 on induction of a virus-neutralizing humoral response . J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. . 12 . 3 . 213–20 . 1996 . 8673525 . 10.1097/00042560-199607000-00001. etal. free .
• Kalsi G, Kuo PH, Aliev F . A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts . Hum. Mol. Genet. . 19 . 12 . 2497–506 . 2010 . 20332099 . 10.1093/hmg/ddq112 . 2876884. etal.
• Levade T, Graber D, Flurin V . Human β-mannosidase deficiency associated with peripheral neuropathy . Ann. Neurol. . 35 . 1 . 116–9 . 1994 . 8285582 . 10.1002/ana.410350119 . 71932852 . etal.
• Hu H, Shioda T, Moriya C . Infectivities of human and other primate lentiviruses are activated by desialylation of the virion surface . J. Virol. . 70 . 11 . 7462–70 . 1996 . 8892864 . 10.1128/jvi.70.11.7462-7470.1996. 190813. etal.
• Yeh JC, Seals JR, Murphy CI . Site-specific N-glycosylation and oligosaccharide structures of recombinant HIV-1 gp120 derived from a baculovirus expression system . Biochemistry . 32 . 41 . 11087–99 . 1993 . 8218172 . 10.1021/bi00092a019. etal.
• Sabourdy F, Labauge P, Stensland HM . A MANBA mutation resulting in residual beta-mannosidase activity associated with severe leukoencephalopathy: a possible pseudodeficiency variant . BMC Med. Genet. . 10. 84 . 2009 . 19728872 . 10.1186/1471-2350-10-84 . free . 2745377. etal.
• Hosgood HD, Zhang L, Shen M . Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity . Occup Environ Med . 66 . 12 . 848–53 . 2009 . 19773279 . 10.1136/oem.2008.044024 . 2928224. etal.
• Alkhayat AH, Kraemer SA, Leipprandt JR . Human beta-mannosidase cDNA characterization and first identification of a mutation associated with human beta-mannosidosis . Hum. Mol. Genet. . 7 . 1 . 75–83 . 1998 . 9384606 . 10.1093/hmg/7.1.75. etal. free .
• Kimura K, Wakamatsu A, Suzuki Y . Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 10.1101/gr.4039406 . 1356129. etal.
• Papandreou MJ, Fenouillet E . Effect of various glycosidase treatments on the resistance of the HIV-1 envelope to degradation . FEBS Lett. . 406 . 1–2 . 191–5 . 1997 . 9109416 . 10.1016/S0014-5793(97)00273-1. 17660 . free .
• Gao J, Arbman G, He L . MANBA polymorphism was related to increased risk of colorectal cancer in Swedish but not in Chinese populations . Acta Oncol . 47 . 3 . 372–8 . 2008 . 17899454 . 10.1080/02841860701644052 . 45674826 . etal.
• Robinson WE, Montefiori DC, Mitchell WM . Evidence that mannosyl residues are involved in human immunodeficiency virus type 1 (HIV-1) pathogenesis . AIDS Res. Hum. Retroviruses . 3 . 3 . 265–82 . 1987 . 2829950 . 10.1089/aid.1987.3.265.
• Montefiori DC, Robinson WE, Mitchell WM . Role of protein N-glycosylation in pathogenesis of human immunodeficiency virus type 1 . Proc. Natl. Acad. Sci. U.S.A. . 85 . 23 . 9248–52 . 1988 . 3264072 . 10.1073/pnas.85.23.9248 . 282716 . 1988PNAS...85.9248M. free .
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928. etal.
• Fenouillet E, Jones I, Powell B . Functional role of the glycan cluster of the human immunodeficiency virus type 1 transmembrane glycoprotein (gp41) ectodomain . J. Virol. . 67 . 1 . 150–60 . 1993 . 8093218 . 10.1128/jvi.67.1.150-160.1993. 237347. etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2002 . 12477932 . 10.1073/pnas.242603899 . 139241. etal . 2002PNAS...9916899M. free .
• Land A, Braakman I . Folding of the human immunodeficiency virus type 1 envelope glycoprotein in the endoplasmic reticulum . Biochimie . 83 . 8 . 783–90 . 2001 . 11530211 . 10.1016/S0300-9084(01)01314-1. 1874/5091 . 13576808 . free .
• Blough HA, Pauwels R, De Clercq E . Glycosylation inhibitors block the expression of LAV/HTLV-III (HIV) glycoproteins . Biochem. Biophys. Res. Commun. . 141 . 1 . 33–8 . 1986 . 3099781 . 10.1016/S0006-291X(86)80330-8. etal.
• Hart ML, Saifuddin M, Spear GT . Glycosylation inhibitors and neuraminidase enhance human immunodeficiency virus type 1 binding and neutralization by mannose-binding lectin . J. Gen. Virol. . 84 . Pt 2 . 353–60 . 2003 . 12560567 . 10.1099/vir.0.18734-0. free .

Notes and References

1. Web site: Entrez Gene: mannosidase.
2. Chen H, Leipprandt JR, Traviss CE, Sopher BL, Jones MZ, Cavanagh KT, Friderici KH . Molecular cloning and characterization of bovine beta-mannosidase . J. Biol. Chem. . 270 . 8 . 3841–8 . February 1995 . 7876128 . 10.1074/jbc.270.8.3841. free .
3. Some enzymes present in highly purified invertase preparations; a contribution to the study of fructofuranosidases, galactosidases, glucosidases and mannosidases . Adams, M. . Richtmyer, N.K. . Hudson, C.S. . amp . J. Am. Chem. Soc. . 1943 . 65 . 1369–1380 . 10.1021/ja01247a029 . 7 .
4. The properties of synovial fluid β-mannosidase activity . Bartholomew, B.A. . Perry, A.L. . amp . Biochim. Biophys. Acta . 1973 . 315 . 123–127 . 4743897 . 10.1016/0005-2744(73)90136-8 . 1.
5. Über den enzymatischen Abbau von Carubin, dem Galaktomannan aus Ceratonia siliqua L . Deuel, H. . Lewuenberger, R. . Huber, G. . amp . Helv. Chim. Acta . 1950 . 33 . 942–946 . 10.1002/hlca.19500330424 . 4 .
6. The enzymatic hydrolysis of Leucaena glauca galactomannan. Isolation of crystalline galactomannan depolymerase . Hylin, J.W. . Sawai, K. . amp . J. Biol. Chem. . 1964 . 239 . 990–992 . 10.1016/S0021-9258(18)91377-3 . 14165949. free .