Benzothiadiazine Explained

Benzothiadiazine is a bicyclic heterocyclic benzene derivative with the heterocycle containing two nitrogens and one sulfur.^[1]

Some benzothiadiazine derivatives are used as pharmaceutical drugs, including:

• bendroflumethiazide^[2]
• chlorothiazide
• cyclothiazide^[3]
• hydrochlorothiazide^[4]
• diazoxide^[5]

Notes and References

1. Hu Z, Martí J, Lu H . Structure of benzothiadiazine at zwitterionic phospholipid cell membranes . The Journal of Chemical Physics . 155 . 15 . 154303 . October 2021 . 34686044 . 10.1063/5.0065163 . 2107.14565 . 2021JChPh.155o4303H . 239471390 .
2. Hu Z, Marti J . In Silico Drug Design of Benzothiadiazine Derivatives Interacting with Phospholipid Cell Membranes . Membranes . 12 . 3 . 331 . March 2022 . 35323806 . 8949146 . 10.3390/membranes12030331 . free .
3. Huwaimel BI, Bhakta M, Kulkarni CA, Milliken AS, Wang F, Peng A, Brookes PS, Trippier PC . 6 . Discovery of Halogenated Benzothiadiazine Derivatives with Anticancer Activity* . ChemMedChem . 16 . 7 . 1143–1162 . April 2021 . 33331124 . 8035258 . 10.1002/cmdc.202000729 .
4. Varano F, Catarzi D, Colotta V, Squarcialupi L, Matucci R . 1,2,4-Benzothiadiazine-1,1-dioxide derivatives as ionotropic glutamate receptor ligands: synthesis and structure-activity relationships . Archiv der Pharmazie . 347 . 11 . 777–785 . November 2014 . 25204434 . 10.1002/ardp.201400192 . 1765795 .
5. Book: Ganeshpurkar A, Gutti G, Singh SK . Chapter 1 - RNA-Dependent RNA Polymerases and Their Emerging Roles in Antiviral Therapy . 2019-01-01 . 10.1016/B978-0-12-815422-9.00001-2 . Viral Polymerases . 1–42 . SP . Academic Press . en . 978-0-12-815422-9 . 92095885 .