Benzodioxan Explained

The benzodioxans are a group of isomeric chemical compounds with the molecular formula C8H8O2.[1] There are three isomers of benzodioxan, as the second atom of oxygen of the dioxane can be in a second, third or fourth position: 1,2-dioxane, 1,3-dioxane and 1,4-dioxane, which respectively give 1,2-benzodioxan, 1,3-benzodioxan and 1,4-benzodioxan.[2] [3]

Derivatives

Some derivatives of 1,4-benzodioxan are used as pharmaceuticals including:[4] [5] [6] [7]

See also

Notes and References

  1. Web site: 1,4-Benzodioxane . live . https://web.archive.org/web/20220905045711/https://pubchem.ncbi.nlm.nih.gov/compound/10301#datasheet=LCSS . 2022-09-05 . 2022-09-05 . . . en.
  2. 2017 . TECHNICAL FACT SHEET – 1,4-DIOXANE . live . Technical Fact Sheet . 51 . 6 . 9 . https://web.archive.org/web/20220813022213/https://www.epa.gov/sites/default/files/2014-03/documents/ffrro_factsheet_contaminant_14-dioxane_january2014_final.pdf . 2022-08-13 . 2022-09-05 . United States Environmental Protection Agency.
  3. Book: Jablonski, Stanley . Russian drug index . . 1967 . Public Health Service publication . U.S. Dept. of Health, Education, and Welfare, Public Health Service . en .
  4. Sun . Juan . Cao . Ning . Zhang . Xiao-Min . Yang . Yu-Shun . Zhang . Yan-Bin . Wang . Xiao-Ming . Zhu . Hai-Liang . 2011-08-15 . Oxadiazole derivatives containing 1,4-benzodioxan as potential immunosuppressive agents against RAW264.7 cells . Bioorganic & Medicinal Chemistry . 19 . 16 . 4895–4902 . 10.1016/j.bmc.2011.06.061 . 1464-3391 . 21782456.
  5. Web site: 1,4-benzodioxan derivatives their preparation and pharmaceutical compositions containing them - Patent IL-43272-A - PubChem . 2022-09-05 . pubchem.ncbi.nlm.nih.gov.
  6. Sun . Juan . Wang . Su . Sheng . Gui-Hua . Lian . Zhi-Min . Liu . Han-Yu . Zhu . Hai-Liang . 2016-11-01 . Synthesis of phenylpiperazine derivatives of 1,4-benzodioxan as selective COX-2 inhibitors and anti-inflammatory agents . Bioorganic & Medicinal Chemistry . 24 . 21 . 5626–5632 . 10.1016/j.bmc.2016.09.023 . 1464-3391 . 27658794.
  7. Matos . M. Agostinha R. . Sousa . Clara C. S. . Morais . Victor M. F. . 2008-08-28 . Experimental and computational thermochemistry of 1,4-benzodioxan and its 6-R derivatives . The Journal of Physical Chemistry A . 112 . 34 . 7961–7968 . 10.1021/jp803579y . 1520-5215 . 18683910. 2008JPCA..112.7961M .

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Benzodioxan".

Except where otherwise indicated, Everything.Explained.Today is © Copyright 2009-2024, A B Cryer, All Rights Reserved. Cookie policy.