Benzaldehyde dehydrogenase (NADP+) explained

benzaldehyde dehydrogenase (NADP+)
Ec Number:	1.2.1.7
Cas Number:	9028-89-1
Go Code:	0018477

In enzymology, a benzaldehyde dehydrogenase (NADP+) is an enzyme that catalyzes the chemical reaction

benzaldehyde + NADP⁺ + H₂O

\rightleftharpoons benzoate + NADPH + 2 H⁺

The 3 substrates of this enzyme are benzaldehyde, NADP⁺, and H₂O, whereas its 3 products are benzoate, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is benzaldehyde:NADP+ oxidoreductase. Other names in common use include NADP+-linked benzaldehyde dehydrogenase, and benzaldehyde dehydrogenase (NADP+). This enzyme participates in benzoate degradation via hydroxylation and toluene and xylene degradation.

References

• GUNSALUS CF, STANIER RY, Gunsalus IC . Irwin Gunsalus . 1953 . THE ENZYMATIC CONVERSION OF MANDELIC ACID TO BENZOIC ACID III. : Fractionation and Properties of the Soluble Enzymes . J. Bacteriol. . 66 . 548 - 53 . 13108854 . 5 . 317432 .
• Stachow CS, Stevenson IL, Day D . 1967 . Purification and properties of nicotinamide adenine dinucleotide phosphate-specific benzaldehyde dehydrogenase from Pseudomonas . J. Biol. Chem. . 242 . 5294 - 300 . 4383635 . 22 .