Colostrum Explained

Colostrum (from Latin, of unknown origin) is the first form of milk produced by the mammary glands of humans and other mammals immediately following delivery of the newborn.[1] It may be called beestings, the traditional word from Old English dialects, when referring to the first milk of a cow or other animals.[2] Most species will begin to generate colostrum just prior to giving birth. Colostrum has an especially high amount of bioactive compounds compared to mature milk to give the newborn the best possible start to life. Specifically, colostrum contains antibodies to protect the newborn against disease and infection, and immune and growth factors and other bioactives that help to activate a newborn's immune system, jumpstart gut function, and seed a healthy gut microbiome in the first few days of life. The bioactives found in colostrum are essential for a newborn's health, growth and vitality. Colostrum strengthens a baby's immune system and is filled with white blood cells to protect it from infection.

At birth, the surroundings of the newborn mammal change from the relatively sterile environment in the mother's uterus, with a constant nutrient supply via the placenta, to the microbe-rich environment outside, with irregular oral intake of complex milk nutrients through the gastrointestinal tract.[3] This transition puts high demands on the gastrointestinal tract of the neonate, as the gut plays an important part in both the digestive system and the immune system.[4] Colostrum has evolved to care for highly sensitive mammalian neonates and contributes significantly to initial immunological defense as well as to the growth, development, and maturation of the neonate's gastrointestinal tract by providing key nutrients and bioactive factors. Bovine colostrum powder is rich in protein and low in sugar and fat.[5] [6] Bovine colostrum can also be used for a range of conditions in humans, and can boost a neonate's immunity.[7]

Colostrum also has a mild laxative effect, encouraging the passing of a baby's first stool, which is called meconium.[8] This clears excess bilirubin, a waste-product of dead red blood cells which is produced in large quantities at birth due to blood volume reduction from the infant's body, and which is often responsible for jaundice.

Bioactive components in colostrum

Newborns have very immature and small digestive systems, and colostrum delivers its bioactives in a very concentrated low-volume form. Colostrum is known to contain immune cells (as lymphocytes)[9] [10] and many antibodies such as IgA, IgG, and IgM. These are some of the components of the adaptive immune system. Other immune components of colostrum include the major components of the innate immune system, such as lactoferrin,[11] lysozyme,[12] lactoperoxidase,[13] complement,[14] and proline-rich polypeptides (PRP).[15] A number of cytokines (small messenger peptides that control the functioning of the immune system) are found in colostrum as well,[16] including interleukins, tumor necrosis factor,[17] chemokines,[18] and others.

Colostrum also contains a number of growth factors, such as insulin-like growth factors I (IGF-1),[19] and II,[20] transforming growth factors alpha,[21] beta 1 and beta 2,[22] [23] fibroblast growth factors,[24] epidermal growth factor,[25] granulocyte-macrophage-stimulating growth factor,[26] platelet-derived growth factor, vascular endothelial growth factor,[27] and colony-stimulating factor-1.[28]

Human colostrum

Colostrum, which is produced for the first two to four days after childbirth, enhances immunity[29] [30] and is believed to have anti-inflammatory properties.[31] It is suggested infants fed with human colostrum have lower incidence of gastrointestinal infections.[32] In addition, colostrum also has a laxative effect, encouraging the baby's body to excrete stool, which helps eliminate excess bilirubin.[33] [34] [35] This helps prevent jaundice and allergies in babies.[36]

Human consumption of bovine colostrum

While it has long been understood that the colostrum a mother produces is vital to a newborn's health in the first few days of life, research has shown that bovine (cow) colostrum and its components can continue to support important biological activities when given to more mature children and adults, so that the benefits of colostrum can extend well beyond the neonatal period of development.[37]

Bovine colostrum and human colostrum are highly similar in their makeup, both containing many of the same antibodies, immune and growth factors, and other nutrients.[38] Because they share so many of the same components, the way they work in the body is also highly similar. The benefit of bovine colostrum for human health has been studied in many areas including:

There is also research suggesting that a large proportion of colostrum is not fit for human consumption "due to tremendous bacterial loads". Salmonella was also detected in 15% of unpasteurised samples.[53] Pasteurisation reduces the bioactive proteins many of the benefits rely upon, however.[54]

Colostrum use in animal husbandry

Colostrum is crucial for newborn farm animals. They receive no passive transfer of immunity via the placenta before birth, so any antibodies that they need have to be ingested (unless supplied by injection or other artificial means). The ingested antibodies are absorbed from the intestine of the neonate.[55] [56] [57] [58] [59] The newborn animal must receive colostrum within 6 hours of being born for maximal absorption of colostral antibodies to occur. Recent studies indicate that colostrum should be fed to bovines within the first thirty minutes to maximize IgG absorption rates.[60] The role of colostrum for newborn animals is to provide nutrition, and essential protection against infection while the immune and digestive systems are developing and maturing. Bovine colostrum provides macro- and micro-nutrients, as well as growth factors, cytokines, nucleosides, oligosaccharides, natural antimicrobials, antioxidants; and a range of immunoglobulins such as IgG, IgA, IgD, IgM and IgE. It is well established that minimal levels of IgG are essential to prevent failure of passive transfer. The iron-binding glycoproteins lactoferrin and transferrin in bovine colostrum assist in attacking pathogens by impacting their cell membrane and making them more susceptible to the immune systems attack by neutrophils. Cytokines present in bovine colostrum enhance B and T cell maturation and increase endogenous antibody production. They also play a major role in regulation of epithelial cell growth and development, proliferation, and restitution. Transfer factors enhance the activity of T cells. Other growth and immune factors such as IGF-1, IGF-2, FGF, EGF, TGF, PDGF, etc.

Bovine colostrum boosts immunity and gut health in all animals. Its rich bioactive components fight bacteria, viruses, and other pathogens. Early, high-quality colostrum is crucial for survival and healthy development. It repairs intestinal damage, improves nutrient absorption, and benefits human and animal babies alike. In calves, colostrum helps develop their gut and prevents death. It reduces infections, antibiotic use, and diarrhea, leading to faster growth and higher profits for farmers.

Colostrum use in companion animals

Much like in humans and production animals, companion animal survival in the newborn stage of life is largely dependent upon colostrum. Companion animal immune systems require several weeks to several months in order to fully develop. Maternal antibodies provide benefit for a relatively short period of time so a gap exists with immune sufficiency where an animal is at risk of infection. Like humans, companion animal immune response changes with age where early life and later in life have similarities. That is, an immune bias whereby the animal has less of an ability to fend off infections and greater prevalence of allergy at both ends of the age spectrum. Stress also affects a companion animal's immune system including changes in environment, diet, etc. Maintaining gut microbial balance is key to maintaining a healthy immune system as well as mucosal integrity, similar to humans. Bovine colostrum has been demonstrated to benefit companion animal immunity and digestive health.

Bovine colostrum plays a role in increasing Ig levels, increasing lymphocyte proliferation stimulating activity and increasing phagocytosis activity. These are supported by other components of colostrum which further enhance the activity of the immune response. The iron binding glycoproteins lactoferrin and transferrin in bovine colostrum assist in attacking pathogens by impacting their cell membrane and making them more susceptible to the immune systems attack by neutrophils. Cytokines present in bovine colostrum enhance B and T cell maturation and increase endogenous antibody production. They also play a major role in regulation of epithelial cell growth and development, proliferation, restitution. Transfer factors enhance the activity of T cells. Other growth and immune factors such as IGF-1, IGF-2, FGF, EGF, TGF, PDGF, etc. Colostrum contains glycomacropeptides which help to regulate appetite. Bovine colostrum boosts animal immunity, leading to stronger vaccine responses, improved gut health, and reduced illness from diarrhea and respiratory issues.

Bovine colostrum history of study and potential future applications

Dairy cattle are naturally exposed to pathogens and produce immunoglobulins against them. These antibodies are present in the cow's bloodstream and in the colostrum. These immunoglobulins are specific to many human pathogens, including Escherichia coli, Cryptosporidium parvum, Shigella flexneri, Salmonella species, Staphylococcus species,[61] and rotavirus (which causes diarrhea in infants). Before the development of antibiotics, colostrum was the main source of immunoglobulins used to fight bacteria. In fact, when Albert Sabin made his first oral vaccine against polio, the immunoglobulin he used came from bovine colostrum.[62] When antibiotics began to appear, interest in colostrum waned, but, now that antibiotic-resistant strains of pathogens have developed, interest is once again returning to natural alternatives to antibiotics, namely, colostrum.[63]

Although bovine colostrum has been consumed by humans for centuries,[64] only in recent decades have we seen an increase in randomized clinical trials to support assertions of health benefits. It is probable that little absorption of intact growth factors and antibodies into the bloodstream occurs, due to digestion in the gastrointestinal tract. However, the presence of casein and other buffering proteins does allow growth factors and other bioactive molecules to pass into the lumen of the small intestine intact, where they can stimulate repair and inhibit microbes, working via local effects.[65] This provides a probable mechanism explaining reductions in gut permeability after colostrum administration in some published studies,[66] [67] [68] while another study found colostrum promising as treatment for distal colitis.[69] Evidence for the beneficial effect of colostrum on extra-gastrointestinal problems is less well developed, due in part to the limited number of randomised double-blind studies published, although a variety of possible uses have been suggested.[70] [71] [72]

The gut plays several important roles including acting as the main pathway for fluid, electrolyte and nutrient absorption while also acting as a barrier to toxic agents present in the gut lumen including acid, digestive enzymes and gut bacteria. It is also a major immunological defence mechanism, detecting natural commensals and triggering immune response when toxic microbes are present. Failure of homeostasis due to trauma, drugs and infectious microbes not only damages the gut but can lead to influx of damaging agents into the bloodstream. These mechanisms have relevance for multiple conditions affecting all areas of the world and socioeconomic groups such as ulcers, inflammation, and infectious diarrhea.[73] There is currently much interest in the potential value of colostrum for the prevention and treatment of these conditions as it is derived from natural sources and can influence damaging factors through multiple pathways including nutritional support, immunological intervention (through its immunoglobulin and other anti-microbial factors) and growth/healing factor constituents.[74] As pointed out by Kelly, inconsistency between results in some published studies may be due in part to variation in dose given and to the timing of the colostrum collection being tested (first milking versus pooled colostrum collected up to day 5 following calving).[75]

Some athletes have used colostrum in an attempt to improve their performance,[76] decrease recovery time,[49] and prevent sickness during peak performance levels.[77] [78] Supplementation with bovine colostrum, 20 grams per day (g/d), in combination with exercise training for eight weeks may increase bone-free lean body mass in active men and women.[79]

Low IGF-1 levels may be associated with dementia in the very elderly, although causation has not been established.[80] Malnutrition can cause low levels of IGF-1,[81] as can obesity.[82] Supplementation with colostrum, which is rich in IGF-1, can be a useful part of a weight reduction program. Although IGF-1 is not absorbed intact by the body, some studies suggest it stimulates the production of IGF-1 when taken as a supplement[83] whereas others do not.[51]

Colostrum also has antioxidant components, such as lactoferrin[84] and hemopexin, which binds free heme in the body.[85]

The Isle of Man had a local delicacy called "Groosniuys", a pudding made with colostrum.[86] In Finland, a baked cheese called Leipäjuusto is traditionally made with either cow colostrum or reindeer milk.

A sweet cheese-like delicacy called 'Junnu' or 'Ginna' is made with colostrum in the south Indian states of Karnataka, Andhra Pradesh and Telangana. It is made with both cow and buffalo milk; in both cases it is the milk produced on the second day after giving birth which is considered best for making this pudding-like delicacy. Colostrum is in very high demand in these states, resulting in product adulteration.[87]

Hyperimmune colostrum

Hyperimmune colostrum is natural bovine colostrum collected from a population of cows immunized repeatedly with a specific pathogen. The colostrum is collected within 24 hours of the cow giving birth. Antibodies towards the specific pathogens or antigens that were used in the immunization are present in higher levels than in the population before treatment. Although some papers have been published stating that specific human pathogens were just as high as in hyperimmune colostrum, and natural colostrum nearly always had higher antibody titers than did the hyperimmune version.[61] Clinical trials[88] have shown that if the immunization is by surface antigens of the bacteria, the Bovine Colostrum Powder [89] can be used to make tablets capable of binding to the bacteria so that they are excreted in stools. This prevents the successful colonization of the gut, which would otherwise lead to bacteria releasing enterotoxigenic materials.

Proline-rich polypeptides

These small immune signaling peptides (PRPs) were independently discovered in colostrum and other sources, such as blood plasma, in the United States,[90] Czechoslovakia and Poland.[91] Hence they appear under various names in the literature, including Colostrinin, CLN, transfer factor and PRP. They function as signal transducing molecules that have the unique effect of modulating the immune system, turning it up when the body comes under attack from pathogens or other disease agents, and damping it when the danger is eliminated or neutralized.[92] At first thought to actually transfer immunity from one immune system to another, it now appears that PRPs simply stimulate cell-mediated immunity.[93]

External links

Notes and References

  1. Ballard . Olivia . Morrow . Ardythe L. . Human Milk Composition . Pediatric Clinics of North America . February 2013 . 60 . 1 . 49–74 . 10.1016/j.pcl.2012.10.002 . 23178060 . 3586783 .
  2. Web site: Beestings . 29 December 2022.
  3. Sangild . P. T. . Thymann . T. . Schmidt . M. . Stoll . B. . Burrin . D. G. . Buddington . R. K. . Invited Review: The preterm pig as a model in pediatric gastroenterology . Journal of Animal Science . 1 October 2013 . 91 . 10 . 4713–4729 . 10.2527/jas.2013-6359 . 23942716 . 3984402 .
  4. Newburg . David S. . Walker . W. Allan . Protection of the Neonate by the Innate Immune System of Developing Gut and of Human Milk . Pediatric Research . January 2007 . 61 . 1 . 2–8 . 10.1203/01.pdr.0000250274.68571.18 . 17211132 . 22878097 . free .
  5. Stelwagen . K. . Carpenter . E. . Haigh . B. . Hodgkinson . A. . Wheeler . T. T. . Immune components of bovine colostrum and milk1 . Journal of Animal Science . 1 April 2009 . 87 . suppl_13 . 3–9 . 10.2527/jas.2008-1377 . 18952725 .
  6. Rathe . Mathias . Müller . Klaus . Sangild . Per Torp . Husby . Steffen . Clinical applications of bovine colostrum therapy: a systematic review . Nutrition Reviews . April 2014 . 72 . 4 . 237–254 . 10.1111/nure.12089 . 24571383 . free .
  7. Kaplan . Merve . Arslan . Ayşenur . Duman . Hatice. Production of Bovine Colostrum for Human Consumption to Improve Health . Frontiers in Pharmacology . 10.3389/fphar.2021.796824 . 2022. 12 . 796824 . 35046820 . 8762312 . free .
  8. Web site: Colostrum harvesting . 29 December 2022.
  9. Web site: It's Only Natural. 2017-06-09.
  10. Bertotto . A. . Castellucci . G. . Fabietti . G. . Scalise . F. . Vaccaro . R. . Lymphocytes bearing the T cell receptor gamma delta in human breast milk. . Archives of Disease in Childhood . 1 November 1990 . 65 . 11 . 1274–1275 . 10.1136/adc.65.11.1274-a . 2147370 . 1792611 .
  11. Groves, M. L. . The isolation of a red protein from milk . Journal of the American Chemical Society . 82 . 3345–3360 . 1960 . 10.1021/ja01498a029 . 13.
  12. Paulík S, Slanina L, Polácek M. Lyzozým v kolostre a krvnom sére teliat a dojníc . Lysozyme in the colostrum and blood of calves and dairy cows . sk . Veterinární medicína (Praha) . 30 . 1 . 21–28 . January 1985 . 3918380 .
  13. Book: 10.1002/9780470715413.ch16 . The Lactoperoxidase-Thiocyanate-Hydrogen Peroxide Antibacterium System . Ciba Foundation Symposium 65 – Oxygen Free Radicals and Tissue Damage . Novartis Foundation Symposia . 2008 . Reiter . Bruno . 65 . 285–294 . 225143 . 978-0-470-71541-3 .
  14. Brock, J. H. . Bactericidal and hemolytic activity of complement in bovine colostrum and serum: effect of proteolytic enzymes and ethylene glycol tetraacetic acid (EGTA) . Annales d'Immunologie . 126C . 4 . 439–451 . 1975 . 1 . Ortega, F. . Piñeiro, A. . 813560 .
  15. Zabłocka A, Janusz M, Rybka K, Wirkus-Romanowska I, Kupryszewski G, Lisowski J. Cytokine-inducing activity of a proline-rich polypeptide complex (PRP) from ovine colostrum and its active nonapeptide fragment analogs . European Cytokine Network . 12 . 3 . 462–7 . 2001 . 11566627 .
  16. Hagiwara K, Kataoka S, Yamanaka H, Kirisawa R, Iwai H. Detection of cytokines in bovine colostrum . Veterinary Immunology and Immunopathology . 76 . 3–4 . 183–90 . October 2000 . 11044552 . 10.1016/S0165-2427(00)00213-0.
  17. Rudloff HE, Schmalstieg FC, Mushtaha AA, Palkowetz KH, Liu SK, Goldman AS. Tumor necrosis factor-alpha in human milk . Pediatric Research . 31 . 1 . 29–33 . January 1992 . 1375729 . 10.1203/00006450-199201000-00005. free .
  18. Maheshwari A, Christensen RD, Calhoun DA. ELR+ CXC chemokines in human milk . Cytokine . 24 . 3 . 91–102 . November 2003 . 14581003 . 10.1016/j.cyto.2003.07.002.
  19. Xu RJ . Development of the newborn GI tract and its relation to colostrum/milk intake: a review . Reprod. Fertil. Dev. . 8 . 1 . 35–48 . 1996 . 8713721 . 10.1071/RD9960035 . vanc.
  20. O'Dell SD, Day IN. Insulin-like growth factor II (IGF-II) . . 30 . 7 . 767–71 . July 1998 . 9722981 . 10.1016/S1357-2725(98)00048-X.
  21. Okada M . Transforming growth factor (TGF)-alpha in human milk . Life Sciences . 48 . 12 . 1151–1156 . 1991 . 2002746 . 10.1016/0024-3205(91)90452-H. vanc. Ohmura E . Kamiya Y . 3 . Murakami . Hitomi . Onoda . Noritaka . Iwashita . Mitsutoshi . Wakai . Kae . Tsushima . Toshio . Shizume . Kazuo.
  22. Saito S, Yoshida M, Ichijo M, Ishizaka S, Tsujii T. Transforming growth factor-beta (TGF-beta) in human milk . Clinical and Experimental Immunology . 94 . 1 . 220–224 . October 1993 . 8403511 . 1534356 . 10.1111/j.1365-2249.1993.tb06004.x.
  23. Tokuyama Y, Tokuyama H. Purification and identification of TGF-beta 2-related growth factor from bovine colostrum . Journal of Dairy Research . 60 . 1 . 99–109 . February 1993 . 8436667 . 10.1017/S0022029900027382. 38562131 .
  24. Hironaka . T. . Ohishi . H. . Masaki . T. . Identification and Partial Purification of a Basic Fibroblast Growth Factor-Like Growth Factor Derived from Bovine Colostrum . Journal of Dairy Science . March 1997 . 80 . 3 . 488–495 . 10.3168/jds.S0022-0302(97)75961-7 . 9098798 . free .
  25. Xiao X, Xiong A, Chen X, Mao X, Zhou X. Epidermal growth factor concentrations in human milk, cow's milk and cow's milk-based infant formulas . Chinese Medical Journal . 115 . 3 . 451–454 . March 2002 . 11940387 .
  26. Playford RJ, Macdonald CE, Johnson WS. Colostrum and milk-derived peptide growth factors for the treatment of gastrointestinal disorders . American Journal of Clinical Nutrition . 72 . 1 . 5–14 . July 2000 . 10871554 . 10.1093/ajcn/72.1.5. free .
  27. Vuorela P, Andersson S, Carpén O, Ylikorkala O, Halmesmäki E. Unbound vascular endothelial growth factor and its receptors in breast, human milk, and newborn intestine . American Journal of Clinical Nutrition . 72 . 5 . 1196–201 . November 2000 . 11063449 . 10.1093/ajcn/72.5.1196. free .
  28. Flidel-Rimon O, Roth P. Effects of milk-borne colony stimulating factor-1 on circulating growth factor levels in the newborn infant . Journal of Pediatrics . 131 . 5 . 748–50 . November 1997 . 9403658 . 10.1016/S0022-3476(97)70105-7.
  29. Thapa . B. R. . 2005-07-01 . Health factors in colostrum . The Indian Journal of Pediatrics . en . 72 . 7 . 579–581 . 10.1007/BF02724182 . 16077241 . 24277138 . 0973-7693.
  30. Web site: The Phases of Breast Milk WIC Breastfeeding Support . wicbreastfeeding.fns.usda.gov . 29 December 2022 . en.
  31. Buescher . E. S. . McIlheran . S. M. . July 1988 . Antioxidant Properties of Human Colostrum . Pediatric Research . en . 24 . 1 . 14–19 . 10.1203/00006450-198807000-00005 . 2842722 . 2334728 . 1530-0447. free .
  32. Goldblum . R. M. . Ahlstedt . S. . Carlsson . B. . Hanson . L. Å . Jodal . U. . Lidin-Janson . G. . Sohl-Åkerlund . A. . October 1975 . Antibody-forming cells in human colostrum after oral immunisation . Nature . en . 257 . 5529 . 797–799 . 10.1038/257797a0 . 1102990 . 1975Natur.257..797G . 4148015 . 1476-4687.
  33. Web site: Bệnh viện An Sinh . 2018-12-03 . Những lợi ích của sữa non . 2024-06-16 . TUOI TRE ONLINE . vi.
  34. Web site: Tĩnh . Báo Hà . 2023-10-30 . Khám phá 4 lợi ích tuyệt vời của sữa non cho trẻ sơ sinh . 2024-06-16 . Báo Hà Tĩnh . vi.
  35. Web site: Sữa non gerllac . 2024-06-16 . vi.
  36. Web site: 2019-05-16 . Sữa non - chìa khóa vàng cho hệ miễn dịch . 2024-06-16 . suckhoedoisong.vn . vi.
  37. Web site: Bovine Colostrum: Overview, Uses, Side Effects, Precautions, Interactions, Dosing and Reviews . www.webmd.com . 29 December 2022 . en.
  38. McGrath . Brian A. . Fox . Patrick F. . McSweeney . Paul L. H. . Kelly . Alan L. . Composition and properties of bovine colostrum: a review . Dairy Science & Technology . March 2016 . 96 . 2 . 133–158 . 10.1007/s13594-015-0258-x . 83925224 . free .
  39. Ulfman . Laurien H. . Leusen . Jeanette H. W. . Savelkoul . Huub F. J. . Warner . John O. . van Neerven . R. J. Joost . Effects of Bovine Immunoglobulins on Immune Function, Allergy, and Infection . Frontiers in Nutrition . 22 June 2018 . 5 . 52 . 10.3389/fnut.2018.00052 . 29988421 . 6024018 . free .
  40. Cesarone . Maria Rosaria . Belcaro . Gianni . Di Renzo . Andrea . Dugall . Mark . Cacchio . Marisa . Ruffini . Irma . Pellegrini . Luciano . Del Boccio . Gilberto . Fano . Filiberto . Ledda . Andrea . Bottari . Angelica . Ricci . Andrea . Stuard . Stefano . Vinciguerra . Giulia . Prevention of Influenza Episodes With Colostrum Compared With Vaccination in Healthy and High-Risk Cardiovascular Subjects: The Epidemiologic Study in San Valentino . Clinical and Applied Thrombosis/Hemostasis . April 2007 . 13 . 2 . 130–136 . 10.1177/1076029606295957 . 17456621 . 22882696 . free .
  41. Saad . Khaled . Abo-Elela . Mohamed Gamil M. . El-Baseer . Khaled A. Abd . Ahmed . Ahmed E. . Ahmad . Faisal-Alkhateeb . Tawfeek . Mostafa S. K. . El-Houfey . Amira A. . Aboul_Khair . Mohamed Diab . Abdel-Salam . Ahmad M. . Abo-elgheit . Amir . Qubaisy . Heba . Ali . Ahmed M. . Abdel-Mawgoud . Eman . Effects of bovine colostrum on recurrent respiratory tract infections and diarrhea in children . Medicine . September 2016 . 95 . 37 . e4560 . 10.1097/MD.0000000000004560 . 27631207 . 5402550 .
  42. Book: Watson . Ronald Ross . Collier . Robert J. . Preedy . Victor R. . Dairy in Human Health and Disease across the Lifespan . 2017 . Academic Press . 978-0-12-809869-1 .
  43. Playford . R . Peptide therapy and the gastroenterologist: colostrum and milk-derived growth factors . Clinical Nutrition . June 2001 . 20 . 101–106 . 10.1054/clnu.2001.0434 .
  44. Patel . Kamlesh . Rana . Rajiv . Pedimune in recurrent respiratory infection and diarrhoea—The Indian experience—The PRIDE study . The Indian Journal of Pediatrics . July 2006 . 73 . 7 . 585–591 . 10.1007/BF02759923 . 16877852 . 26464312 . free .
  45. Gopal . Pramod K. . Gill . H. S. . Oligosaccharides and glycoconjugates in bovine milk and colostrum . British Journal of Nutrition . November 2000 . 84 . S1 . 69–74 . 10.1017/s0007114500002270 . 11242449 . free .
  46. Mehra . Rahul . Garhwal . Renu . Sangwan . Karnam . Guiné . Raquel P. F. . Lemos . Edite Teixeira . Buttar . Harpal Singh . Visen . Pradeep Kumar Singh . Kumar . Naveen . Bhardwaj . Anuradha . Kumar . Harish . 2022-02-04 . Insights into the Research Trends on Bovine Colostrum: Beneficial Health Perspectives with Special Reference to Manufacturing of Functional Foods and Feed Supplements . Nutrients . 14 . 3 . 659 . 10.3390/nu14030659 . free . 2072-6643 . 8840100 . 35277018.
  47. Barakat . Sana Hosny . Meheissen . Marwa Ahmed . Omar . Omneya Magdy . Elbana . Doaa Ali . 5 June 2019 . Bovine Colostrum in the Treatment of Acute Diarrhea in Children: A Double-Blinded Randomized Controlled Trial . Journal of Tropical Pediatrics . 66 . 1 . 46–55 . 10.1093/tropej/fmz029 . 31168590.
  48. Huppertz . Hans-Iko . Rutkowski . Stefan . Busch . Dirk H. . Eisebit . Reinhard . Lissner . Reinhard . Karch . Helge . Bovine Colostrum Ameliorates Diarrhea in Infection with Diarrheagenic Escherichia coli, Shiga Toxin-Producing E. coli, and E. coli Expressing Intimin and Hemolysin . Journal of Pediatric Gastroenterology & Nutrition . October 1999 . 29 . 4 . 452–456 . 10.1097/00005176-199910000-00015 . 10512407 . free .
  49. Buckley . J. D. . Abbott . M. J. . Brinkworth . G. D. . Whyte . P. B. D. . Bovine colostrum supplementation during endurance running training improves recovery, but not performance . Journal of Science and Medicine in Sport . June 2002 . 5 . 2 . 65–79 . 10.1016/s1440-2440(02)80028-7 . 12188088 .
  50. Brinkworth . Grant D. . Buckley . Jonathan D. . Slavotinek . John P. . Kurmis . Andrew P. . Effect of bovine colostrum supplementation on the composition of resistance trained and untrained limbs in healthy young men . European Journal of Applied Physiology . 1 January 2004 . 91 . 1 . 53–60 . 10.1007/s00421-003-0944-x . 14504943 . 35803322 .
  51. Duff . Whitney R. D. . Chilibeck . Philip D. . Rooke . Julianne J. . Kaviani . Mojtaba . Krentz . Joel R. . Haines . Deborah M. . The Effect of Bovine Colostrum Supplementation in Older Adults During Resistance Training . International Journal of Sport Nutrition and Exercise Metabolism . June 2014 . 24 . 3 . 276–285 . 10.1123/ijsnem.2013-0182 . 24281841 .
  52. Kotsis . Yiannis . Mikellidi . Anastasia . Aresti . Cleopatra . Persia . Eleni . Sotiropoulos . Aristomenis . Panagiotakos . Demosthenes B. . Antonopoulou . Smaragdi . Nomikos . Tzortzis . A low-dose, 6-week bovine colostrum supplementation maintains performance and attenuates inflammatory indices following a Loughborough Intermittent Shuttle Test in soccer players . European Journal of Nutrition . April 2018 . 57 . 3 . 1181–1195 . 10.1007/s00394-017-1401-7 . 28285432 . 5861165 .
  53. Houser. B. A.. 2008. A Survey of Bacteriological Quality and the Occurrence of Salmonella in Raw Bovine Colostrum. Foodborne Pathogens and Disease. 5. 6. 853–858. 10.1089/fpd.2008.0141. 18991543. Researchgate.net.
  54. Dominguez. E.. Perez. M. D.. Calvo. M.. 1997. Effect of heat treatment on the antigen-binding activity of anti-peroxidase immunoglobulins in bovine colostrum. Journal of Dairy Science. 80. 12. 3182–3187. 10.3168/jds.S0022-0302(97)76290-8. 0022-0302. 9436097. free.
  55. Balfour . W. E. . Comline . R. S. . Acceleration of the absorption of unchanged globulin in the new-born calf by factors in colostrum . The Journal of Physiology . 1 February 1962 . 160 . 2 . 234–257 . 10.1113/jphysiol.1962.sp006844 . 16992118 . 1359530 .
  56. Bush . L. J. . Staley . T. E. . Absorption of Colostral Immunoglobulins in Newborn Calves . Journal of Dairy Science . April 1980 . 63 . 4 . 672–680 . 10.3168/jds.S0022-0302(80)82989-4 . 6991559 . free .
  57. Staley . T. E. . Bush . L. J. . Receptor Mechanisms of the Neonatal Intestine and Their Relationship to Immunoglobulin Absorption and Disease . Journal of Dairy Science . January 1985 . 68 . 1 . 184–205 . 10.3168/jds.S0022-0302(85)80812-2 . 3884680 . free .
  58. Jensen . Annette R. . Elnif . Jan . Burrin . Douglas G. . Sangild . Per T. . Development of Intestinal Immunoglobulin Absorption and Enzyme Activities in Neonatal Pigs Is Diet Dependent . The Journal of Nutrition . 1 December 2001 . 131 . 12 . 3259–3265 . 10.1093/jn/131.12.3259 . 11739877 . free .
  59. Sawyer . M . Willadsen . CH . Osburn . BI . McGuire . TC . Passive transfer of colostral immunoglobulins from ewe to lamb and its influence on neonatal lamb mortality . Journal of the American Veterinary Medical Association . 15 December 1977 . 171 . 12 . 1255–9 . 604324 . vanc.
  60. Pakkanen R, Aalto J . Growth Factors and Antimicrobial Factors of Bovine Colostrum . International Dairy Journal . 1997 . 7 . 285–297 . 10.1016/S0958-6946(97)00022-8 . 5 . vanc.
  61. McConnell . Michelle A. . Buchan . Glenn . Borissenko . Michail V. . Brooks . Heather J. L. . A comparison of IgG and IgG1 activity in an early milk concentrate from non-immunised cows and a milk from hyperimmunised animals . Food Research International . 2001 . 34 . 2–3 . 255–261 . 10.1016/S0963-9969(00)00163-0 .
  62. Sabin . A. B. . Antipoliomyelitic substance in milk of human beings and certain cows . A.M.A. American Journal of Diseases of Children . November 1950 . 80 . 5 . 866–7 . 14777169 .
  63. Pallasch . Thomas J. . Antibiotic prophylaxis: problems in paradise . Dental Clinics of North America . October 2003 . 47 . 4 . 665–679 . 10.1016/s0011-8532(03)00037-5 . 14664458 .
  64. Book: 10.1016/B978-0-12-809868-4.00001-7 . Health Benefits of Bovine Colostrum in Children and Adults . Dairy in Human Health and Disease Across the Lifespan . 2017 . Buttar . Harpal S. . Bagwe . Siddhi M. . Bhullar . Sukhwinder K. . Kaur . Ginpreet . 3–20 . 978-0-12-809868-4 .
  65. Playford . R. J. . Woodman . A. C. . Vesey . D. . Deprez . P. H. . Calam . J. . Watanapa . P. . Williamson . R. C. N. . Clark . P. . Effect of luminal growth factor preservation on intestinal growth . The Lancet . April 1993 . 341 . 8849 . 843–848 . 10.1016/0140-6736(93)93057-8 . 8096559 . 30904879 .
  66. Davison . Glen . Marchbank . Tania . March . Daniel S. . Thatcher . Rhys . Playford . Raymond J. . Zinc carnosine works with bovine colostrum in truncating heavy exercise–induced increase in gut permeability in healthy volunteers . The American Journal of Clinical Nutrition . August 2016 . 104 . 2 . 526–536 . 10.3945/ajcn.116.134403 . 27357095 . free . 2160/43902 . free .
  67. Marchbank . Tania . Davison . Glen . Oakes . Jemma R. . Ghatei . Mohammad A. . Patterson . Michael . Moyer . Mary Pat . Mary Pat Moyer . Playford . Raymond J. . The nutriceutical bovine colostrum truncates the increase in gut permeability caused by heavy exercise in athletes . American Journal of Physiology. Gastrointestinal and Liver Physiology . March 2011 . 300 . 3 . G477–G484 . 10.1152/ajpgi.00281.2010 . 21148400 . 1829471 .
  68. Playford . Raymond J. . Macdonald . Christopher E. . Calnan . Denis P. . Floyd . David N. . Podas . Theo . Johnson . Wendy . Wicks . Anthony C. . Bashir . O. . Marchbank . Tania . Co-administration of the health food supplement, bovine colostrum, reduces the acute non-steroidal anti-inflammatory drug-induced increase in intestinal permeability . Clinical Science . 1 June 2001 . 100 . 6 . 627–633 . 10.1042/cs1000627 . 11352778 . 24586050 .
  69. Khan . Z. . Macdonald . C. . Wicks . A. C. . Holt . M. P. . Floyd . D. . Ghosh . S. . Wright . N. A. . Playford . R. J. . Use of the 'nutriceutical', bovine colostrum, for the treatment of distal colitis: results from an initial study . Alimentary Pharmacology & Therapeutics . November 2002 . 16 . 11 . 1917–1922 . 10.1046/j.1365-2036.2002.01354.x . 12390100 . 30564496 . free .
  70. Uruakpa . F. . Ismond . M. A. H. . Akobundu. E. N. T. . 2002. Colostrum and its benefits: a review. Nutrition Research. 22. 6. 755–767. 10.1016/S0271-5317(02)00373-1.
  71. Playford . R. J. . Floyd . D. N. . Macdonald . C. E. . Calnan . D. P. . Adenekan . R. O. . Johnson . W. . Goodlad . R. A. . Marchbank . T. . May 1999 . Bovine colostrum is a health food supplement which prevents NSAID induced gut damage . Gut . 44 . 5 . 653–658 . 10.1136/gut.44.5.653 . 1727496 . 10205201.
  72. Carver . J. D. . Barness . L. A. . June 1996 . Trophic factors for the gastrointestinal tract . Clinics in Perinatology . 23 . 2 . 265–285 . 10.1016/S0095-5108(18)30242-2 . 8780905.
  73. Baumgart . Daniel C. . Dignass . Axel U. . Intestinal barrier function . Current Opinion in Clinical Nutrition and Metabolic Care . November 2002 . 5 . 6 . 685–694 . 10.1097/00075197-200211000-00012 . 12394645 . 2326543 .
  74. Playford . Raymond J. . Macdonald . Christopher E. . Johnson . Wendy S. . Colostrum and milk-derived peptide growth factors for the treatment of gastrointestinal disorders . The American Journal of Clinical Nutrition . 1 July 2000 . 72 . 1 . 5–14 . 10.1093/ajcn/72.1.5 . 10871554 . free .
  75. Kelly . G. S. . Bovine colostrums: a review of clinical uses . Alternative Medicine Review . November 2003 . 8 . 4 . 378–394 . 14653766 .
  76. Hofman . Zandrie . Smeets . Rolf . Verlaan . George . Lugt . Richard V. D. . Verstappen . Peter A. . The Effect of Bovine Colostrum Supplementation on Exercise Performance in Elite Field Hockey Players . International Journal of Sport Nutrition and Exercise Metabolism . December 2002 . 12 . 4 . 461–469 . 10.1123/ijsnem.12.4.461 . 12500989 .
  77. Ray . Playford . etal . The nutriceutical, bovine colostrum, truncates the increase in gut permeability caused by heavy exercise in athletes . American Journal of Physiology. Gastrointestinal and Liver Physiology . March 2011. 300 . 3 . G477-84 . 10.1152/ajpgi.00281.2010 . 21148400 .
  78. Berk . L. S. . Nieman . D. C. . Youngberg . W. S. . Arabatzis . K. . Simpson-Westerberg . M. . Lee . J. W. . Tan . S. A. . Eby . W. C. . The effect of long endurance running on natural killer cells in marathoners . Medicine and Science in Sports and Exercise . April 1990 . 22 . 2 . 207–212 . 2355818 .
  79. Antonio . Jose . Sanders . Michael S. . Van Gammeren . Darin . The effects of bovine colostrum supplementation on body composition and exercise performance in active men and women . Nutrition . March 2001 . 17 . 3 . 243–247 . 10.1016/s0899-9007(00)00552-9 . 11312068 .
  80. Arai . Y. . Hirose . N. . Yamamura . K. . Shimizu . K.-i. . Takayama . M. . Ebihara . Y. . Osono . Y. . Serum Insulin-like Growth Factor-1 in Centenarians: Implications of IGF-1 as a Rapid Turnover Protein . The Journals of Gerontology Series A: Biological Sciences and Medical Sciences . 1 February 2001 . 56 . 2 . M79–M82 . 10.1093/gerona/56.2.m79 . 11213280 . free .
  81. Caregaro . L. . Favaro . A. . Santonastaso . P. . Alberino . F. . Di Pascoli . L. . Nardi . M. . Favaro . S. . Gatta . A. . Insulin-like growth factor 1 (IGF-1), a nutritional marker in patients with eating disorders . Clinical Nutrition . June 2001 . 20 . 3 . 251–257 . 10.1054/clnu.2001.0397 . 11407872 .
  82. Rasmussen . Michael Højby . Frystyk . Jan . Andersen . Teis . Breum . Leif . Christiansen . Jens Sandahl . Hilsted . Jannik . The impact of obesity, fat distribution, and energy restriction on insulin-like growth factor-1 (IGF-1), IGF-binding protein-3, insulin, and growth hormone . Metabolism . March 1994 . 43 . 3 . 315–319 . 10.1016/0026-0495(94)90099-x . 7511202 .
  83. Mero . Antti . Kähkönen . Jonne . Nykänen . Tarja . Parviainen . Tapani . Jokinen . Ilmari . Takala . Timo . Nikula . Tuomo . Rasi . Simo . Leppäluoto . Juhani . IGF-I, IgA, and IgG responses to bovine colostrum supplementation during training . Journal of Applied Physiology . 1 August 2002 . 93 . 2 . 732–739 . 10.1152/japplphysiol.00002.2002 . 12133885 . 10568424 .
  84. Wakabayashi . Hiroyuki . Matsumoto . Hiroshi . Hashimoto . Koichi . Teraguchi . Susumu . Takase . Mitsunori . Hayasawa . Hirotoshi . Inhibition of Iron/Ascorbate-Induced Lipid Peroxidation by an N-Terminal Peptide of Bovine Lactoferrin and Its Acylated Derivatives . Bioscience, Biotechnology, and Biochemistry . January 1999 . 63 . 5 . 955–957 . 10.1271/bbb.63.955 . 10380640 . free .
  85. Gutteridge . J. M. . Smith . A. . Antioxidant protection by haemopexin of haem-stimulated lipid peroxidation . Biochemical Journal . 15 December 1988 . 256 . 3 . 861–865 . 10.1042/bj2560861 . 3223958 . 1135495 .
  86. 1991. Cooking and Food. Manx Farming and Country Life. 9. 2017-08-03. https://web.archive.org/web/20100215091118/http://www.gov.im/lib/docs/mnh/education/manxfarmingcountrylife/9%20COOKING%20AND%20FOOD.pdf. 2010-02-15. dead.
  87. News: K.. Bhumika. 2017-05-18. The milky way. en-IN. The Hindu. 2021-04-21 .
  88. Otto . Wlodzimierz . Najnigier . Boguslaw . Stelmasiak . Teodor . Robins-Browne . Roy M. . Randomized control trials using a tablet formulation of hyperimmune bovine colostrum to prevent diarrhea caused by enterotoxigenic Escherichia coli in volunteers . Scandinavian Journal of Gastroenterology . July 2011 . 46 . 7–8 . 862–868 . 10.3109/00365521.2011.574726 . 21526980 . 3154584 .
  89. TGA guidance BCP
  90. Lawrence . H. S. . The Cellular Transfer of Cutaneous Hypersensitivity to Tuberculin in Man . Experimental Biology and Medicine . 1 August 1949 . 71 . 4 . 516–522 . 10.3181/00379727-71-17242 . 18139800 . 37728884 .
  91. Janusz . Maria . Lisowski . Józef . Franěk . Frantisěk . Isolation and characterization of a proline-rich polypeptide from ovine colostrum . FEBS Letters . 15 December 1974 . 49 . 2 . 276–279 . 10.1016/0014-5793(74)80529-6 . 4442608 . 2495375 . free . 1974FEBSL..49..276J .
  92. Book: 10.1007/978-0-387-74087-4_9 . A Proline-Rich Polypeptide from Ovine Colostrum: Colostrinin with Immunomodulatory Activity . Bioactive Components of Milk . Advances in Experimental Medicine and Biology . 2008 . Zimecki . Michal . 606 . 241–250 . 18183932 . 978-0-387-74086-7 .
  93. Levin . A. S. . Spitler . L. E. . Fudenberg . H. H. . Transfer factor I: methods of therapy . Birth Defects Original Article Series . 1975 . 11 . 1 . 445–448 . 1080060 .

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