Basal cell adhesion molecule explained

Basal cell adhesion molecule, also known as Lutheran antigen, is a plasma membrane glycoprotein that in humans is encoded by the BCAM gene.[1] BCAM has also recently been designated CD239 (cluster of differentiation 239).

Function

Lutheran blood group glycoprotein is a member of the immunoglobulin superfamily and a receptor for the extracellular matrix protein, laminin. The protein contains five, N-terminus, extracellular immunoglobulin domains, a single transmembrane domain, and a short, C-terminal cytoplasmic tail. This protein may play a role in epithelial cell cancer and in vaso-occlusion of red blood cells in sickle cell disease. Two transcript variants encoding different isoforms have been found for this gene.

Interactions

BCAM has been shown to interact with Laminin, alpha 5. BCAM has also been shown to promote the metastasis of ovarian cancer.[2] [3] [4]

Further reading

Notes and References

  1. Web site: Entrez Gene: BCAM basal cell adhesion molecule (Lutheran blood group).
  2. Parsons SF, Lee G, Spring FA, Willig TN, Peters LL, Gimm JA, Tanner MJ, Mohandas N, Anstee DJ, Chasis JA . Lutheran blood group glycoprotein and its newly characterized mouse homologue specifically bind alpha5 chain-containing human laminin with high affinity . Blood . 97 . 1 . 312–20 . 2001 . 11133776 . 10.1182/blood.v97.1.312. 10715366 . free .
  3. Kikkawa Y, Moulson CL, Virtanen I, Miner JH . Identification of the binding site for the Lutheran blood group glycoprotein on laminin alpha 5 through expression of chimeric laminin chains in vivo . J. Biol. Chem. . 277 . 47 . 44864–9 . 2002 . 12244066 . 10.1074/jbc.M208731200 . free .
  4. Sivakumar S, Lieber S, Librizzi D. Basal cell adhesion molecule promotes metastasis-associated processes in ovarian cancer . Clin Transl Med . 13 . 1. 2023 . e1176 . 36647260 . 10.1002/ctm2.1176 . 9842900 . free.