Baruol synthase explained

Baruol synthase
Ec Number:	5.4.99.57

Baruol synthase (BARS1) is an enzyme with systematic name (3S)-2,3-epoxy-2,3-dihydrosqualene mutase (cyclizing, baruol-forming).^[1] This enzyme catalyses the following chemical reaction

(3S)-2,3-epoxy-2,3-dihydrosqualene

\rightleftharpoons baruol

The enzyme from Arabidopsis thaliana also produces traces of 22 other triterpenoids.

Notes and References

1. Lodeiro S, Xiong Q, Wilson WK, Kolesnikova MD, Onak CS, Matsuda SP . An oxidosqualene cyclase makes numerous products by diverse mechanisms: a challenge to prevailing concepts of triterpene biosynthesis . Journal of the American Chemical Society . 129 . 36 . 11213–22 . September 2007 . 17705488 . 10.1021/ja073133u .