Barbigerone Explained

Barbigerone is one of a few pyranoisoflavones among several groups of isoflavones. It was first isolated from the seed of a leguminous plant Tephrosia barbigera; hence the name "barbigerone".[1] Members of the genus Millettia are now known to be rich in barbigerone, including M. dielsiena,[2] M. ferruginea,[3] M. usaramensis,[4] and M. pachycarpa.[5] It has also been isolated from the medicinal plant Sarcolobus globosus.[6] Barbigerone from S. globosus is validated to have significant antioxidant property.[7] Barbigerone exhibits profound antiplasmodial activity against the malarial parasite Plasmodium falciparum.[8] It is also demonstrated that it has anti-cancer potential as it causes apoptosis of murine lung-cancer cells.[9]

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Notes and References

  1. Vilain C . 1980 . Barbigerone, next term a new pyranoisoflavone from seeds of Tephrosia barbigera . Phytochemistry . 19 . 5 . 10.1016/0031-9422(80)85162-4 . 988.
  2. 10.1055/s-0028-1112203 . Novel benzil and isoflavone derivatives from Millettia dielsiana . 236–242 . 19140097 . 2009 . Gong . Ting . Wang . Dong-Xiao . Chen . Ruo-Yun . Liu . Ping . Yu . De-Quan . Planta Medica . 75 . 3.
  3. Dagne E, Bekele A . 1990 . C-prenylated isoflavones from Millettia ferruginea . Phytochemistry . 29 . 8 . 2679–2682 . 10.1016/0031-9422(90)85212-X.
  4. Rotenoids, isoflavones and chalcones from the stem bark of Millettia usaramensis subspecies usaramensis . Phytochemistry . 10.1016/S0031-9422(97)00424-X . 1998 . Yenesew . Abiy . Midiwo . Jacob O. . Waterman . Peter G. . 47 . 2 . 295.
  5. Enrichment and isolation of barbigerone from Millettia pachycarpa Benth. using high-speed counter-current chromatography and preparative HPLC . 20187026 . 10.1002/jssc.200900641 . https://archive.today/20130105080935/http://www3.interscience.wiley.com/journal/123301902/abstract . dead . 2013-01-05 . 2010 . Ye . Haoyu . Zhong . Shijie . Li . Yanfang . Tang . Minghai . Peng . Aihua . Hu . Jia . Shi . Jie . He . Shicao . Wu . Wenshuang . Chen . Lijuan . Journal of Separation Science . 1010–7 . 33 . 8.
  6. Rotenoids and isoflavones from Sarcolobus globosus . 754–758 . 16142641 . 2005 . Wangensteen . H . Alamgir . M . Rajia . S . Samuelsen . AB . Malterud . KE . 71 . 8 . 10.1055/s-2005-864182 . Planta Medica.
  7. Antioxidant and 15-lipoxygenase inhibitory activity of rotenoids, isoflavones and phenolic glycosides from Sarcolobus globosus . Fitoterapia . 16701962 . 77 . 4 . 290–295 . 10.1016/j.fitote.2006.03.017 . 2006 . Wangensteen . H . Miron . A . Alamgir . M . Rajia . S . Samuelsen . AB . Malterud . KE.
  8. Anti-plasmodial activities and X-ray crystal structures of rotenoids from Millettia usaramensis subspecies usaramensis . Phytochemistry . 64 . 3 . 773–779 . 13679101 . 10.1016/S0031-9422(03)00373-X . 2003 . Yenesew . A . Derese . S . Midiwo . JO . Oketch-Rabah . HA . Lisgarten . J . Palmer . R . Heydenreich . M . Peter . MG . Akala . H . Wangui . J . Liyala . P . Waters . NC.
  9. Barbigerone, a natural isoflavone, induces apoptosis in murine lung-cancer cells via the mitochondrial apoptotic pathway . 24 . 1–2 . 95–104 . 19590197 . 2009 . Li . ZG . Zhao . YL . Wu . X . Ye . HY . Peng . A . Cao . ZX . Mao . YQ . Zheng . YZ . Jiang . PD . Zhao . X . Chen . LJ . Wei . YQ . 10.1159/000227817 . Cellular Physiology and Biochemistry. free .

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