Bactobolin Explained

Bactobolin is a cytotoxic, polyketide-peptide and antitumor antibiotic with the molecular formula C₁₄H₂₀Cl₂N₂O₆.^{[1] [2] [3] [4]} Bactobolin was discovered in 1979.^[5]

Further reading

• Weinreb . S. M. . Garigipati . R. S. . Design of an efficient strategy for total synthesis of the microbial metabolite (-)-bactobolin . Pure and Applied Chemistry . 1 January 1989 . 61 . 3 . 435–438 . 10.1351/pac198961030435. free .
• Book: Lukacs . Gabor . Ohno . Masaji . Recent Progress in the Chemical Synthesis of Antibiotics . 6 December 2012 . Springer Science & Business Media . 978-3-642-75617-7 . 286 . en.
• Book: Kocienski . Philip J. . Protecting Groups, 3rd Edition 2005 . 14 May 2014 . Georg Thieme Verlag . 978-3-13-179153-5 . 554 . en.

Notes and References

1. Greenberg . E. Peter . Chandler . Josephine R. . Seyedsayamdost . Mohammad R. . The Chemistry and Biology of Bactobolin: A 10-Year Collaboration with Natural Product Chemist Extraordinaire Jon Clardy . Journal of Natural Products . 27 March 2020 . 83 . 3 . 738–743 . 10.1021/acs.jnatprod.9b01237. 32105069 . 8118907 . 1808/32425 . free .
2. Weinreb . Steven M. . Total synthesis of the microbial antitumor antibiotics actinobolin and bactobolin . Studies in Natural Products Chemistry . 1995 . 16 . 3–25 . 10.1016/S1572-5995(06)80051-7. 9780444822642 .
3. Munakata . Tomohiko . Ikeda . Yoshifumi . Matsuki . Hideo . Isagai . Katsuyoshi . Cultural Conditions and Strain Improvement for Production of Bactobolin . Agricultural and Biological Chemistry . May 1983 . 47 . 5 . 929–934 . 10.1080/00021369.1983.10865772.
4. Book: Franco . Carlos M. . Belda . Beatriz Vázquez . Natural Compounds as Antimicrobial Agents . 2 December 2020 . MDPI . 978-3-03936-048-2 . 134 . en.
5. Book: Reinhoudt . D. N. . Connors . T. A. . Pinedo . H. M. . Poll . K. W. van de . Structure-Activity Relationships of Anti-Tumour Agents . 6 December 2012 . Springer Science & Business Media . 978-94-009-6798-4 . 270 . en.