Bacopaside Explained

Bacopasides are triterpene saponins isolated from Bacopa monnieri. Members of this class of compounds include:

• Bacopaside I, shows antidepressant-like effects in a mouse model^[1]
• Bacopaside II^[2]
• Bacopaside III^{[3] [4]}
• Bacopaside IV^[4]
• Bacopaside V^[4]
• Bacopaside VI^[5]
• Bacopaside VII^[5]
• Bacopaside VIII^[5]
• Bacopaside IX^[6]
• Bacopaside X^[6]
• Bacopaside XI, shows nootropic activity in a mouse model^[6]

Notes and References

1. 23872136. 2013. Liu. X. Liu. F. Yue. R. Li. Y. Zhang. J. Wang. S. Zhang. S. Wang. R. Shan. L. Zhang. W. The antidepressant-like effect of bacopaside I: Possible involvement of the oxidative stress system and the noradrenergic system. 110. 224–30. 10.1016/j.pbb.2013.07.007. Pharmacology Biochemistry and Behavior. 23612866.
2. 11576596. 2001. Chakravarty. AK. Sarkar. T. Masuda. K. Shiojima. K. Nakane. T. Kawahara. N. Bacopaside I and II: Two pseudojujubogenin glycosides from Bacopa monniera. 58. 4. 553–6. Phytochemistry. 10.1016/S0031-9422(01)00275-8.
3. 12502309. 2002. Hou. CC. Lin. SJ. Cheng. JT. Hsu. FL. Bacopaside III, bacopasaponin G, and bacopasides A, B, and C from Bacopa monniera. 65. 12. 1759–63. 10.1021/np020238w. Journal of Natural Products.
4. 12576661 . 2003 . Chakravarty . AK . Garai . S . Masuda . K . Nakane . T . Kawahara . N . Bacopasides III-V: Three new triterpenoid glycosides from Bacopa monniera . 51 . 2 . 215–7 . Chemical & Pharmaceutical Bulletin . 10.1248/cpb.51.215. free .
5. 17343408. 2007. Zhou. Y. Shen. YH. Zhang. C. Su. J. Liu. RH. Zhang. WD. Triterpene saponins from Bacopa monnieri and their antidepressant effects in two mice models. 70. 4. 652–5. 10.1021/np060470s. Journal of Natural Products.
6. 19214943. 2009. Zhou. Y. Peng. L. Zhang. WD. Kong. DY. Effect of triterpenoid saponins from Bacopa monniera on scopolamine-induced memory impairment in mice. 75. 6. 568–74. 10.1055/s-0029-1185339. Planta Medica.