Azumolene Explained

Azumolene is an experimental drug which is a derivative of dantrolene. In animal studies, azumolene showed similar efficacy to dantrolene at controlling symptoms of malignant hyperthermia but with better water solubility and lower toxicity, albeit with lower potency.^{[1] [2] [3]}

Notes and References

1. Sudo RT, Carmo PL, Trachez MM, Zapata-Sudo G . Effects of azumolene on normal and malignant hyperthermia-susceptible skeletal muscle . Basic & Clinical Pharmacology & Toxicology . 102 . 3 . 308–16 . March 2008 . 18047479 . 10.1111/j.1742-7843.2007.00156.x . free .
2. do Carmo PL, Zapata-Sudo G, Trachez MM, Antunes F, Guimarães SE, Debom R, Rizzi MD, Sudo RT . 6 . Intravenous administration of azumolene to reverse malignant hyperthermia in swine . Journal of Veterinary Internal Medicine . 2010 . 24 . 5 . 1224–8 . 20584138 . 10.1111/j.1939-1676.2010.0556.x . free .
3. Thota S, Rodrigues DA, Pinheiro PS, Lima LM, Fraga CA, Barreiro EJ . N-Acylhydrazones as drugs . Bioorganic & Medicinal Chemistry Letters . 28 . 17 . 2797–2806 . September 2018 . 30006065 . 10.1016/j.bmcl.2018.07.015 . 51625222 .