Azasteroid Explained

An azasteroid is a type of steroid derivative which has one of the carbon atoms in the steroid ring system replaced by a nitrogen atom. Two azasteroids, finasteride and dutasteride, are used clinically as 5α-reductase inhibitors.^{[1] [2] [3]}

Some of the 6-azasteroids may prove to be useful drugs, but have yet to reach the pharmaceutical market.^{[4] [5]}

Notes and References

1. Book: Enrique Ravina. The Evolution of Drug Discovery: From Traditional Medicines to Modern Drugs. 11 January 2011. John Wiley & Sons. 978-3-527-32669-3. 183–.
2. Book: Roger S. Kirby. John D. McConnell. John M. Fitzpatrick. Claus G. Roehrborn . Peter Boyle. Textbook of Benign Prostatic Hyperplasia, Second Edition. 29 November 2004. CRC Press. 978-1-901865-55-4. 321–.
3. Singh. Shankar. Gauthier. Sylvain. Labrie. Fernand. Androgen Receptor Antagonists (Antiandrogens) Structure-Activity Relationships. Current Medicinal Chemistry. 7. 2. 2000. 211–247. 0929-8673. 10.2174/0929867003375371. 10637363.
4. 10.1021/jm00078a022. 8277514. 6-Azasteroids: Potent dual inhibitors of human type 1 and 2 steroid 5.alpha.-reductase. Journal of Medicinal Chemistry. 36. 26. 4313–5. 1993. Frye. Stephen V.. Haffner. Curt D.. Maloney. Patrick R.. Mook. Robert A.. Dorsey. G. F.. Hiner. Roger N.. Batchelor. Kenneth W.. Bramson. H. Neal. Stuart. J. Darren.
5. 10.1021/jm00041a014. 8057283. 6-Azasteroids: Structure-Activity Relationships for Inhibition of Type 1 and 2 Human 5.alpha.-Reductase and Human Adrenal 3.beta.-Hydroxy-.DELTA.5-steroid Dehydrogenase/3-Keto-.DELTA.5-steroid Isomerase. Journal of Medicinal Chemistry. 37. 15. 2352–60. 1994. Frye. Stephen V.. Haffner. Curt D.. Maloney. Patrick R.. Mook. Robert A.. Dorsey. George F.. Hiner. Roger N.. Cribbs. Cindy M.. Wheeler. Thomas N.. Ray. John A..