Aurein Explained

Symbol:	Antimicrobial20
Antimicrobial20
Pfam:	PF08256
Interpro:	IPR013157
Tcdb:	1.C.76
Opm Family:	211
Opm Protein:	1vm5

This family of antibacterial peptides are secreted from the granular dorsal glands of Litoria aurea (Green and golden bell frog), Litoria raniformis (Southern bell frog), Litoria citropa (Australian blue mountains tree frog) and frogs from genus Uperoleia. Amongst the more active of these are aurein 1.2,^[1] aurein 2.2 and aurein 3.1; caerin 1.1, maculatin 1.1, uperin 3.6;^[2] citropin 1.1, citropin 1.2, citropin 1.3 and a minor peptide are wide-spectrum antibacterial peptides.^{[3] [4]}

Notes and References

1. Web site: Differential Stability of Aurein 1.2 Pores in Model Membranes of Two Probiotic Strains . 2023-10-03 . 10.1021/acs.jcim.0c00855.s001 .
2. Rozek T, Wegener KL, Bowie JH, Olver IN, Carver JA, Wallace JC, Tyler MJ . The antibiotic and anticancer active aurein peptides from the Australian Bell Frogs Litoria aurea and Litoria raniformis the solution structure of aurein 1.2 >. Eur. J. Biochem. . 267 . 17 . 5330–41 . September 2000 . 10951191 . 10.1046/j.1432-1327.2000.01536.x.
3. Wegener KL, Wabnitz PA, Carver JA, Bowie JH, Chia BC, Wallace JC, Tyler MJ . Host defence peptides from the skin glands of the Australian blue mountains tree-frog Litoria citropa. Solution structure of the antibacterial peptide citropin 1.1 . Eur. J. Biochem. . 265 . 2 . 627–37 . October 1999 . 10504394 . 10.1046/j.1432-1327.1999.00750.x. free .
4. Shahmiri . Mahdi . Enciso . Marta . Mechler . Adam . Controls and constrains of the membrane disrupting action of Aurein 1.2 . Scientific Reports . 17 November 2015 . 5 . 1 . 16378 . 10.1038/srep16378 . 26574052 . 4648102 . 2015NatSR...516378S .