Atroxase Explained

Atroxase
Ec Number:	3.4.24.43
Cas Number:	181186-94-7

Atroxase is an enzyme.^[1] This enzyme catalyses the following chemical reaction

Cleavage of His⁵-Leu, Ser⁹-His, His¹⁰-Leu, Ala¹⁴-Leu and Tyr¹⁶-Leu of insulin B chain

This endopeptidase is present in the venom of the western diamondback rattlesnake (Crotalus atrox).

Notes and References

1. Willis TW, Tu AT . Purification and biochemical characterization of atroxase, a nonhemorrhagic fibrinolytic protease from western diamondback rattlesnake venom . Biochemistry . 27 . 13 . 4769–77 . June 1988 . 3167016 . 10.1021/bi00413a028 .