MAGI2 explained

Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 also known as membrane-associated guanylate kinase inverted 2 (MAGI-2) and atrophin-1-interacting protein 1 (AIP-1) is an enzyme that in humans is encoded by the MAGI2 gene.^{[1] [2] [3]}

Function

The protein encoded by this gene interacts with atrophin-1. Atrophin-1 contains a polyglutamine repeat, expansion of which is responsible for dentatorubral-pallidoluysian atrophy. This encoded protein is characterized by two WW domains, a guanylate kinase-like domain, and multiple PDZ domains. It has structural similarity to the membrane-associated guanylate kinase homologue (MAGUK) family.^[3]

Interactions

MAGI2 has been shown to interact with ATN1^[4] and PTEN (gene).

Further reading

• Wood JD, Yuan J, Margolis RL, etal . Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins. . Mol. Cell. Neurosci. . 11 . 3 . 149–60 . 1998 . 9647693 . 10.1006/mcne.1998.0677 . 20003277 . free .
• Toward a complete human genome sequence. . Genome Res. . 8 . 11 . 1097–108 . 1999 . 9847074 . 10.1101/gr.8.11.1097. Sanger Centre . The . Washington University Genome Sequencing Cente . The . free .
• Ide N, Hata Y, Deguchi M, etal . Interaction of S-SCAM with neural plakophilin-related Armadillo-repeat protein/delta-catenin. . Biochem. Biophys. Res. Commun. . 256 . 3 . 456–61 . 1999 . 10080919 . 10.1006/bbrc.1999.0364 .
• Wu X, Hepner K, Castelino-Prabhu S, etal . Evidence for regulation of the PTEN tumor suppressor by a membrane-localized multi-PDZ domain containing scaffold protein MAGI-2. . Proc. Natl. Acad. Sci. U.S.A. . 97 . 8 . 4233–8 . 2000 . 10760291 . 10.1073/pnas.97.8.4233 . 18208 . 2000PNAS...97.4233W . free .
• Xu J, Paquet M, Lau AG, etal . beta 1-adrenergic receptor association with the synaptic scaffolding protein membrane-associated guanylate kinase inverted-2 (MAGI-2). Differential regulation of receptor internalization by MAGI-2 and PSD-95. . J. Biol. Chem. . 276 . 44 . 41310–7 . 2001 . 11526121 . 10.1074/jbc.M107480200 . free .
• Vazquez F, Grossman SR, Takahashi Y, etal . Phosphorylation of the PTEN tail acts as an inhibitory switch by preventing its recruitment into a protein complex. . J. Biol. Chem. . 276 . 52 . 48627–30 . 2002 . 11707428 . 10.1074/jbc.C100556200 . free .
• Nishimura W, Yao I, Iida J, etal . Interaction of synaptic scaffolding molecule and Beta -catenin. . J. Neurosci. . 22 . 3 . 757–65 . 2002 . 11826105 . 6758496 . 10.1523/JNEUROSCI.22-03-00757.2002. free .
• Nakayama M, Kikuno R, Ohara O . Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs. . Genome Res. . 12 . 11 . 1773–84 . 2003 . 12421765 . 10.1101/gr.406902 . 187542 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Yap CC, Muto Y, Kishida H, etal . PKC regulates the delta2 glutamate receptor interaction with S-SCAM/MAGI-2 protein. . Biochem. Biophys. Res. Commun. . 301 . 4 . 1122–8 . 2003 . 12589829 . 10.1016/S0006-291X(03)00070-6 .
• Scherer SW, Cheung J, MacDonald JR, etal . Human chromosome 7: DNA sequence and biology. . Science . 300 . 5620 . 767–72 . 2003 . 12690205 . 2882961 . 10.1126/science.1083423 . 2003Sci...300..767S .
• Hillier LW, Fulton RS, Fulton LA, etal . The DNA sequence of human chromosome 7. . Nature . 424 . 6945 . 157–64 . 2003 . 12853948 . 10.1038/nature01782 . 2003Natur.424..157H . free .
• Evgrafov OV, Mersiyanova I, Irobi J, etal . Mutant small heat-shock protein 27 causes axonal Charcot-Marie-Tooth disease and distal hereditary motor neuropathy. . Nat. Genet. . 36 . 6 . 602–6 . 2004 . 15122254 . 10.1038/ng1354 . free .
• Franklin JL, Yoshiura K, Dempsey PJ, etal . Identification of MAGI-3 as a transforming growth factor-alpha tail binding protein. . Exp. Cell Res. . 303 . 2 . 457–70 . 2005 . 15652357 . 10.1016/j.yexcr.2004.10.007 .
• Hu Y, Li Z, Guo L, etal . MAGI-2 Inhibits cell migration and proliferation via PTEN in human hepatocarcinoma cells. . Arch. Biochem. Biophys. . 467 . 1 . 1–9 . 2007 . 17880912 . 10.1016/j.abb.2007.07.027 .

Notes and References

1. Shoji H, Tsuchida K, Kishi H, Yamakawa N, Matsuzaki T, Liu Z, Nakamura T, Sugino H . Identification and characterization of a PDZ protein that interacts with activin type II receptors . J Biol Chem . 275 . 8 . 5485–92 . Mar 2000 . 10681527 . 10.1074/jbc.275.8.5485 . free .
2. Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O . Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro . DNA Res . 5 . 3 . 169–76 . Dec 1998 . 9734811 . 10.1093/dnares/5.3.169 . free .
3. Web site: Entrez Gene: MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2.
4. Wood . J D . Yuan J . Margolis R L . Colomer V . Duan K . Kushi J . Kaminsky Z . Kleiderlein J J . Sharp A H . Ross C A . Jun 1998 . Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins . Mol. Cell. Neurosci. . 11 . 3 . 149–60 . United States. 1044-7431. 9647693 . 10.1006/mcne.1998.0677 . 20003277 . free .