Atrolysin B Explained

Atrolysin B
Ec Number:3.4.24.41
Cas Number:172306-48-8

Atrolysin B (Crotalus atrox metalloendopeptidase b, hemorrhagic toxin b, Ht-b) is an enzyme.[1] [2] This enzyme catalyses the following chemical reaction

Cleavage of His5-Leu, His10-Leu, Ala14-Leu, Tyr16-Leu and Gly23-Phe of insulin B chain; identical to the cleavage of insulin B chain by atrolysin C. Also cleaves -Ser bonds in glucagon

This enzyme is present in the western diamondback rattlesnake (Crotalus atrox).

Notes and References

  1. Bjarnason JB, Tu AT . Hemorrhagic toxins from Western diamondback rattlesnake (Crotalus atrox) venom: isolation and characterization of five toxins and the role of zinc in hemorrhagic toxin e . Biochemistry . 17 . 16 . 3395–404 . August 1978 . 210790 . 10.1021/bi00609a033 .
  2. Bjarnason JB, Hamilton D, Fox JW . Studies on the mechanism of hemorrhage production by five proteolytic hemorrhagic toxins from Crotalus atrox venom . Biological Chemistry Hoppe-Seyler . 369 Suppl . 121–9 . May 1988 . 3060135 .

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