Aspergillusol A Explained

Aspergillusol A is an alpha-glucosidase inhibitor isolated from marine Aspergillus.[1] Structurally, it consists of an erythritol group in the center, with two hydroxyimino-phenylpropanoyl groups attached to it from either side. It was synthesized in 2010 by researchers from King Fahd University of Petroleum and Minerals, starting with 4-hydroxybenzaldehyde.[2]

Notes and References

  1. 19824618. 2009. Ingavat. N. Dobereiner. J. Wiyakrutta. S. Mahidol. C. Ruchirawat. S. Kittakoop. P. Aspergillusol A, an alpha-glucosidase inhibitor from the marine-derived fungus Aspergillus aculeatus. 72. 11. 2049–52. 10.1021/np9003883. Journal of Natural Products.
  2. Ullah . N. . Haladu . S. A. . The first total synthesis of aspergillusol A, an alpha-glucosidase inhibitor . Natural Product Communications . 5 . 7 . 1077–1080 . 2010 . 10.1177/1934578X1000500719 . 20734944. 29175958 . free .

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