| Aspartate—ammonia ligase (ADP-forming) | |
| Ec Number: | 6.3.1.4 |
| Cas Number: | 37318-61-9 |
| Go Code: | 0047478 |
In enzymology, an aspartate—ammonia ligase (ADP-forming) is an enzyme that catalyzes the chemical reaction
ATP + L-aspartate + NH3
\rightleftharpoons
The 3 substrates of this enzyme are ATP, L-aspartate, and NH3, whereas its 3 products are ADP, phosphate, and L-asparagine.
This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds as acid-D-ammonia (or amine) ligases (amide synthases). The systematic name of this enzyme class is L-aspartate:ammonia ligase (ADP-forming). Other names in common use include asparagine synthetase (ADP-forming), and asparagine synthetase (adenosine diphosphate-forming). This enzyme participates in nitrogen metabolism.