Asoprisnil ecamate explained

Asoprisnil ecamate (INN) (developmental code name J-956) is a synthetic, steroidal selective progesterone receptor modulator (SPRM) which was under development for the treatment of endometriosis, uterine fibroids, and menopausal symptoms but was discontinued.^{[1] [2] [3]} It is a potent and highly selective ligand of the progesterone receptor with mixed agonistic and antagonistic activity and much reduced antiglucocorticoid activity relative to mifepristone.^[4] The drug reached phase III clinical trials for the aforementioned indications prior to its discontinuation.

See also

• Asoprisnil
• Ulipristal acetate
• Vilaprisan

External links

• Asoprisnil ecamate – AdisInsight

Notes and References

1. Web site: Asoprisnil - AdisInsight.
2. Schubert G, Elger W, Kaufmann G, Schneider B, Reddersen G, Chwalisz K . Discovery, chemistry, and reproductive pharmacology of asoprisnil and related 11beta-benzaldoxime substituted selective progesterone receptor modulators (SPRMs) . Seminars in Reproductive Medicine . 23 . 1 . 58–73 . 2005 . 15714390 . 10.1055/s-2005-864034 . 260316786 .
3. Chwalisz K, Perez MC, Demanno D, Winkel C, Schubert G, Elger W . Selective progesterone receptor modulator development and use in the treatment of leiomyomata and endometriosis . Endocrine Reviews. 26 . 3 . 423–38 . 2005 . 15857972 . 10.1210/er.2005-0001 . free .
4. Chwalisz K, Garg R, Brenner R, Slayden O, Winkel C, Elger W . Role of nonhuman primate models in the discovery and clinical development of selective progesterone receptor modulators (SPRMs) . Reproductive Biology and Endocrinology . 4 . S8 . 2006 . Suppl 1 . 17118172 . 1775068 . 10.1186/1477-7827-4-S1-S8 . free .