Asialoglycoprotein Explained

If terminal sialic acid residues are removed from glycoproteins, the resulting proteins are known as asialoglycoproteins.^{[1] [2]}

In rats, the exposure of subterminal galactose or GalNAc residues may assist in receptor-mediated endocytosis of asialoglycoproteins by asialoglycoprotein receptors on Kuppfer cells. The human ortholog of this gene is non-functional, but hepatocyte asialoglycoprotein receptors are functional in both humans and rats.^[3]

Notes and References

1. Gross . Hans Jürgen . Brossmer . Reinhard . 1987-06-01 . N-Acetyl-4-deoxy-d-neuraminic acid is activated and transferred on to asialoglycoprotein . Glycoconjugate Journal . en . 4 . 2 . 145–156 . 10.1007/BF01049452 . 7911178 . 1573-4986.
2. Regoeczi . E. . Chindemi . P. A. . 1981-01-01 . The net weight of the rabbit liver and its relevance for asialoglycoprotein clearance . Growth . 45 . 1 . 19–28 . 0017-4793 . 7227848.
3. Fadden AJ, Holt OJ, Drickamer K. Glycobiology. 13. 7. 2003. 529-537. 10.1093/glycob/cwg068. 12672702. free. Molecular characterization of the rat Kupffer cell glycoprotein receptor.