Arylesterase Explained

arylesterase
Ec Number:	3.1.1.2
Cas Number:	9032-73-9
Go Code:	0004064

The enzyme arylesterase (EC 3.1.1.2) catalyzes the reaction

a phenyl acetate + H₂O

\rightleftharpoons a phenol + acetate

This enzyme belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. The systematic name of this enzyme class is aryl-ester hydrolase. Other names in common use include A-esterase, paraoxonase, and aromatic esterase. This enzyme participates in bisphenol a degradation.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes and .

References

• ALDRIDGE WN . 1953 . Serum esterases. I. Two types of esterase (A and B) hydrolysing p-nitrophenyl acetate, propionate and butyrate, and a method for their determination . Biochem. J. . 53 . 110 - 7 . 13032041 . 1 . 1198110 . 10.1042/bj0530110.
• AUGUSTINSSON KB, OLSSON B . 1959 . Esterases in the milk and blood plasma of swine. I. Substrate specificity and electrophoresis studies . Biochem. J. . 71 . 477 - 84 . 13638253 . 3 . 10.1042/bj0710477 . 1196820 .
• Bosmann HB . 1972 . Membrane marker enzymes. Characterization of an arylesterase of guinea pig cerebral cortex utilizing p-nitrophenyl acetate as substrate . Biochim. Biophys. Acta . 276 . 180 - 91 . 5047702 . 1 . 10.1016/0005-2744(72)90019-8.
• Kim DH, Yang YS, Jakoby WB . 1990 . Nonserine esterases from rat liver cytosol . Protein Expr. Purif. . 1 . 19 - 27 . 2152179 . 10.1016/1046-5928(90)90040-6 . 1 .
• Mackness MI, Thompson HM, Hardy AR, Walker CH . 1987 . Distinction between 'A'-esterases and arylesterases. Implications for esterase classification . Biochem. J. . 245 . 293 - 6 . 2822017 . 1 . 1148115 . 10.1042/bj2450293.
• Khersonsky O, Tawfik DS . Apr 2005. Structure-reactivity studies of serum paraoxonase PON1 suggest that its native activity is lactonase.. 15835926 . Biochemistry . 44. 16. 6371–82. 10.1021/bi047440d.
• June 2005. Human paraoxonases (PON1, PON2, and PON3) are lactonases with overlapping and distinct substrate specificities. 15772423 . Draganov DI, Teiber JF, Speelman A, Osawa Y, Sunahara R, La Du BN . 46. 1239–47. 10.1194/jlr.M400511-JLR200 . J. Lipid Res.. 6. free.
• 10.1194/jlr.m400511-jlr200 . 46 . Human paraoxonases (PON1, PON2, and PON3) are lactonases with overlapping and distinct substrate specificities . The Journal of Lipid Research . 1239–1247 . 15772423 . June 2005 . Draganov DI, Teiber JF, Speelman A, Osawa Y, Sunahara R, La Du BN. 6 . free .