Arylamine N-acetyltransferase explained

arylamine N-acetyltransferase
Ec Number:	2.3.1.5
Cas Number:	9027-33-2
Go Code:	0004060

In enzymology, an arylamine N-acetyltransferase is an enzyme that catalyzes the chemical reaction

acetyl-CoA + an arylamine

\rightleftharpoons CoA + an N-acetylarylamine

Thus, the two substrates of this enzyme are acetyl-CoA and arylamine, whereas its two products are CoA and N-acetylarylamine.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acetyl-CoA:arylamine N-acetyltransferase. Other names in common use include arylamine acetylase, beta-naphthylamine N-acetyltransferase, 4-aminobiphenyl N-acetyltransferase, acetyl CoA-arylamine N-acetyltransferase, 2-naphthylamine N-acetyltransferase, arylamine acetyltransferase, indoleamine N-acetyltransferase, N-acetyltransferase, p-aminosalicylate N-acetyltransferase, serotonin acetyltransferase, and serotonin N-acetyltransferase.

Structural studies

As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes,,,,,, and .

References

• CHOU TC, LIPMANN F . 1952 . Separation of acetyl transfer enzymes in pigeon liver extract . J. Biol. Chem. . 196 . 89 - 103 . 12980945 . 1 .
• Paul RC, Ratledge C . 1973 . Further studies on anthranilate N-acetyltransferase and the metabolism of N-acetylanthranilic acid in Aerobacter aerogenes . Biochim. Biophys. Acta . 320 . 9 - 15 . 4748369 . 1 . 10.1016/0304-4165(73)90160-8.
• Tabor H, Mehler AH, Stadtman ER . 1953 . The enzymatic acetylation of amines . J. Biol. Chem. . 204 . 1 . 127 - 138 . 13084583.
• Weissbach H, Redfield BG, Axelrod J . 1961 . The enzymic acetylation of serotonin and other naturally occurring amines . Biochim. Biophys. Acta . 54 . 1 . 190 - 192 . 10.1016/0006-3002(61)90954-4 . 14005907.