Arylacetonitrilase Explained

arylacetonitrilase
Ec Number:	3.5.5.5
Cas Number:	132053-06-6
Go Code:	0047428

In enzymology, an arylacetonitrilase is an enzyme that catalyzes the chemical reaction

4-chlorophenylacetonitrile + 2 H₂O

\rightleftharpoons 4-chlorophenylacetate + NH₃

Thus, the two substrates of this enzyme are 4-chlorophenylacetonitrile and H₂O, whereas its two products are 4-chlorophenylacetate and NH₃.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in nitriles. The systematic name of this enzyme class is arylacetonitrile aminohydrolase. This enzyme participates in cyanoamino acid metabolism.

References

• Mauger J, Nagasawa T, Yamada H . 1990 . Occurrence of a novel nitrilase, arylacetonitrilase, in Alcaligenes faecalis JM3 . Arch. Microbiol. . 155 . 1 - 6 . 10.1007/BF00291265 .
• Nagasawa T, Mauger J, Yamada H . 1990 . A novel nitrilase, arylacetonitrilase, of Alcaligenes faecalis JM3 Purification and characterization . Eur. J. Biochem. . 194 . 765 - 72 . 2269298 . 10.1111/j.1432-1033.1990.tb19467.x . 3 . free .