Artemisinic aldehyde Delta11(13)-reductase explained

Artemisinic aldehyde Delta11(13)-reductase
Ec Number:	1.3.1.92

Artemisinic aldehyde Delta11(13)-reductase (Dbr2) is an enzyme with systematic name artemisinic aldehyde:NADP⁺ oxidoreductase.^{[1] [2]} This enzyme catalyses the following chemical reaction

(11R)-dihydroartemisinic aldehyde + NADP⁺

\rightleftharpoons artemisinic aldehyde + NADPH + H⁺

This enzyme i present in Artemisia annua.

Notes and References

1. Bertea CM, Freije JR, van der Woude H, Verstappen FW, Perk L, Marquez V, De Kraker JW, Posthumus MA, Jansen BJ, de Groot A, Franssen MC, Bouwmeester HJ . Identification of intermediates and enzymes involved in the early steps of artemisinin biosynthesis in Artemisia annua . Planta Medica . 71 . 1 . 40–7 . January 2005 . 15678372 . 10.1055/s-2005-837749 . free .
2. Zhang Y, Teoh KH, Reed DW, Maes L, Goossens A, Olson DJ, Ross AR, Covello PS . The molecular cloning of artemisinic aldehyde Delta11(13) reductase and its role in glandular trichome-dependent biosynthesis of artemisinin in Artemisia annua . The Journal of Biological Chemistry . 283 . 31 . 21501–8 . August 2008 . 18495659 . 10.1074/jbc.M803090200 . free .