Arsenate reductase (cytochrome c) explained

Arsenate reductase (cytochrome c)
Ec Number:	1.20.2.1

Arsenate reductase (cytochrome c) (arsenite oxidase) is an enzyme with systematic name arsenite:cytochrome c oxidoreductase.^{[1] [2] [3] [4]} This enzyme catalyses the following chemical reaction

arsenite + H₂O + 2 oxidized cytochrome c

\rightleftharpoons arsenate + 2 reduced cytochrome c + 2 H⁺

Arsenate reductase is a molybdoprotein isolated from alpha-proteobacteria that contains iron-sulfur clusters.

Notes and References

1. vanden Hoven RN, Santini JM . Arsenite oxidation by the heterotroph Hydrogenophaga sp. str. NT-14: the arsenite oxidase and its physiological electron acceptor . Biochimica et Biophysica Acta (BBA) - Bioenergetics . 1656 . 2–3 . 148–55 . June 2004 . 15178476 . 10.1016/j.bbabio.2004.03.001 . free .
2. Santini JM, Kappler U, Ward SA, Honeychurch MJ, vanden Hoven RN, Bernhardt PV . The NT-26 cytochrome c552 and its role in arsenite oxidation . Biochimica et Biophysica Acta (BBA) - Bioenergetics . 1767 . 2 . 189–96 . February 2007 . 17306216 . 10.1016/j.bbabio.2007.01.009 . free .
3. Branco R, Francisco R, Chung AP, Morais PV . Identification of an aox system that requires cytochrome c in the highly arsenic-resistant bacterium Ochrobactrum tritici SCII24 . Applied and Environmental Microbiology . 75 . 15 . 5141–7 . August 2009 . 19525272 . 2725503 . 10.1128/aem.02798-08 .
4. Lieutaud A, van Lis R, Duval S, Capowiez L, Muller D, Lebrun R, Lignon S, Fardeau ML, Lett MC, Nitschke W, Schoepp-Cothenet B . Arsenite oxidase from Ralstonia sp. 22: characterization of the enzyme and its interaction with soluble cytochromes . The Journal of Biological Chemistry . 285 . 27 . 20433–41 . July 2010 . 20421652 . 2898339 . 10.1074/jbc.m110.113761 . free .