Arogenate dehydrogenase (NAD(P)+) explained

Arogenate dehydrogenase (NAD(P)+)
Ec Number:	1.3.1.79
Cas Number:	64295-75-6

In enzymology, an arogenate dehydrogenase [NAD(P)+] is an enzyme that catalyzes the chemical reaction

L-arogenate + NAD(P)+

\rightleftharpoons L-tyrosine + NAD(P)H + CO₂

The 3 substrates of this enzyme are L-arogenate, NAD⁺, and NADP⁺, whereas its 4 products are L-tyrosine, NADH, NADPH, and CO₂.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is L-arogenate:NAD(P)+ oxidoreductase (decarboxylating). Other names in common use include arogenic dehydrogenase (ambiguous), cyclohexadienyl dehydrogenase, and pretyrosine dehydrogenase (ambiguous).

References

• Connelly JA, Conn EE . Eric Conn (biochemist) . 1986 . Tyrosine biosynthesis in Sorghum bicolor: isolation and regulatory properties of arogenate dehydrogenase . Z. Naturforsch. C . 41 . 69 - 78 . 2939643 . 1–2 . 10.1515/znc-1986-1-212 . free .
• Book: Bonner C, Jensen R . Arogenate dehydrogenase . 1987 . Metabolism of Aromatic Amino Acids and Amines . 142 . 488 - 94 . 3600376 . 10.1016/S0076-6879(87)42060-0 . Methods in Enzymology . 978-0-12-182042-8 .