Arogenate dehydrogenase explained

cyclohexadienyl dehydrogenase
Ec Number:	1.3.1.43
Cas Number:	64295-75-6
Go Code:	0047794

In enzymology, an arogenate dehydrogenase is an enzyme that catalyzes the chemical reaction

L-arogenate + NAD⁺

\rightleftharpoons L-tyrosine + NADH + CO₂

Thus, the two substrates of this enzyme are L-arogenate and NAD⁺, whereas its 3 products are L-tyrosine, NADH, and CO₂.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is L-arogenate:NAD+ oxidoreductase (decarboxylating). Other names in common use include arogenic dehydrogenase (ambiguous), cyclohexadienyl dehydrogenase, pretyrosine dehydrogenase (ambiguous), and L-arogenate:NAD+ oxidoreductase. This enzyme participates in phenylalanine, tyrosine and tryptophan biosynthesis and novobiocin biosynthesis.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code .

References

• Stenmark SL, Pierson DL, Jensen RA, Glover GI . 1974 . Blue-green bacteria synthesise L-tyrosine by the pretyrosine pathway . Nature . 247 . 290 - 2 . 4206476 . 10.1038/247290a0 . 439 . 1974Natur.247..290S . 4200115 .
• Byng G, Whitaker R, Flick C, Jensen RA . 1981 . Enzymology of L-tyrosine biosynthesis in corn (Zea mays) . . 20 . 1289 - 1292 . 10.1016/0031-9422(81)80023-4 . 6 . 1981PChem..20.1289B .
• Mayer E, Waldner-Sander S, Keller B, Keller E, Lingens F . 1985 . Purification of arogenate dehydrogenase from Phenylobacterium immobile . FEBS Lett. . 179 . 208 - 12 . 3967752 . 10.1016/0014-5793(85)80519-6 . 2 . 35594546 . free . 1985FEBSL.179..208M .
• Book: Lingens F, Keller E, Keller B . Arogenate dehydrogenase from Phenylobacterium immobile . 1987 . Metabolism of Aromatic Amino Acids and Amines . 142 . 513 - 518 . 10.1016/S0076-6879(87)42064-8 . Methods in Enzymology . 978-0-12-182042-8 .
• Zamir LO, Tiberio R, Devor KA, Sauriol F, Ahmad S, Jensen RA . 1988 . Structure of D-prephenyllactate. A carboxycyclohexadienyl metabolite from Neurospora crassa . J. Biol. Chem. . 263 . 17284 - 90 . 2972718 . 33 . 10.1016/S0021-9258(19)77833-8 . free .