Argopsin Explained

Argopsin, also known as 1-chloropannarin, is a secondary metabolite produced by many lichen species, such as Biatora cuprea^[1] and Micarea lignaria.^[2] Argopsin was first isolated from the lichen Argopsis friesiana.^[3] The chemical composition of argopsin is 2,7-Dichloro-3-hydroxy-8-methoxy-1,6,9-trimethyl-11-oxo-11H-dibenzo[b,e][1,4]dioxepin-4-carbaldehyde.

Uses

Argopsin can have photohemolytic effect when activated under ultraviolet light with a wavelength of 366 nm.^[4]

Argopsin has been shown to have in vitro effect on Leishmania at a concentration of 50 μg/ml.^[5]

Notes and References

1. Hörður Kristinsson (2016). Íslenskar fléttur. Reykjavík: Hið íslenska bókmenntafélag. ISBN 978-9979-66-347-8
2. Flóra Íslands. Viðarkúpa - Micarea lignaria. Sótt 4. mars 2017.
3. 10.1016/0031-9422(75)85363-5 . 1'-Chloropannarin, a new depsidone from Argopsis friesiana: Notes on the structure of pannarin and on the chemistry of the lichen genus Argopsis . 1975 . Huneck . Siegfried . Lamb . I.Mackenzee . Phytochemistry . 14 . 7 . 1625–1628 .
4. 8289110. 1993. Hidalgo. M. E.. Fernández. E.. Quilhot. W.. Lissi. E. A.. Photohemolytic activity of lichen metabolites. Journal of Photochemistry and Photobiology. B, Biology. 21. 1. 37–40. 10.1016/1011-1344(93)80161-2.
5. 10.1016/S0742-8413(96)00127-2 . Activity of Compounds Isolated from Chilean Lichens Against Experimental Cutaneous Leishmaniasis . 1997 . Fournet . Alain . Ferreira . Maria-Elena . De Arias . Antonieta Rojas . De Ortiz . Susana Torres . Inchausti . Alba . Yalaff . Gloria . Quilhot . Wanda . Fernandez . Ernesto . Hidalgo . Maria Elena . Comparative Biochemistry and Physiology Part C: Pharmacology, Toxicology and Endocrinology . 116 . 1 . 51–54 . 9080673 .