Arginine N-succinyltransferase explained
| arginine N-succinyltransferase |
| Ec Number: | 2.3.1.109 |
| Cas Number: | 99676-48-9 |
| Go Code: | 0008791 |
In enzymology, an arginine N-succinyltransferase is an enzyme that catalyzes the chemical reaction
succinyl-CoA + L-arginine
CoA + N
2-succinyl-L-arginine
Thus, the two substrates of this enzyme are succinyl-CoA and L-arginine, whereas its two products are CoA and N2-succinyl-L-arginine.[1]
This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is succinyl-CoA:L-arginine N2-succinyltransferase. Other names in common use include arginine succinyltransferase, AstA, arginine and ornithine N2-succinyltransferase, AOST, AST, and succinyl-CoA:L-arginine 2-N-succinyltransferase. This enzyme participates in arginine and proline metabolism.
Structural studies
As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code .
Further reading
- Vander Wauven C, Jann A, Haas D, Leisinger T, Stalon V . 1988 . N2-succinylornithine in ornithine catabolism of Pseudomonas aeruginosa . Arch. Microbiol. . 150 . 400 - 4 . 3144259 . 10.1007/BF00408314 . 4 . 12934236 .
- Vander Wauven C, Stalon V . 1985 . Occurrence of succinyl derivatives in the catabolism of arginine in Pseudomonas cepacia . J. Bacteriol. . 164 . 882 - 6 . 2865249 . 2 . 10.1128/JB.164.2.882-886.1985 . 214334 .
- Tricot C, Vander Wauven C, Wattiez R, Falmagne P, Stalon V . 1994 . Purification and properties of a succinyltransferase from Pseudomonas aeruginosa specific for both arginine and ornithine . Eur. J. Biochem. . 224 . 853 - 61 . 7523119 . 10.1111/j.1432-1033.1994.00853.x . 3 . free .
- Itoh Y . 1997 . Cloning and characterization of the aru genes encoding enzymes of the catabolic arginine succinyltransferase pathway in Pseudomonas aeruginosa . J. Bacteriol. . 179 . 7280 - 90 . 9393691 . 23 . 179677 . 10.1128/jb.179.23.7280-7290.1997 .
- Schneider BL, Kiupakis AK, Reitzer LJ . 1998 . Arginine catabolism and the arginine succinyltransferase pathway in Escherichia coli . J. Bacteriol. . 180 . 4278 - 86 . 9696779 . 16 . 10.1128/JB.180.16.4278-4286.1998 . 107427 .
- Cunin R, Glansdorff N, Pierard A, Stalon V . 1986 . Biosynthesis and metabolism of arginine in bacteria . Microbiol. Rev. . 50 . 314 - 52 . 3534538 . 3 . 10.1128/MMBR.50.3.314-352.1986 . 373073 .
- Cunin R, Glansdorff N, Pierard A, Stalon V . 1987 . Erratum report: Biosynthesis and metabolism of arginine in bacteria . Microbiol. Rev. . 51 . 178 . 16350242 . 1 . 373097 .
Notes and References
- Web site: N(2)-Succinyl-L-arginine (Compound) on National Center for Biotechnology Information USA.
