Arachidonyl-2'-chloroethylamide explained

Arachidonyl-2'-chloroethylamide (ACEA) is a synthetic agonist of the CB₁ (CB1R). ACEA is considered to be a selective cannabinoid agonist as it binds primarily to the CB1R and has low affinity to the CB₂ (CB2R) (K_i = 1.4 nM for CB1R; K_i = 3100 nM for CB2R). ^[1]

Notes and References

1. 10336536 . 1999 . Hillard . CJ . Manna . S . Greenberg . MJ . Dicamelli . R . Ross . RA . Stevenson . LA . Murphy . V . Pertwee . RG . Campbell . WB . Synthesis and characterization of potent and selective agonists of the neuronal cannabinoid receptor (CB1) . 289 . 3 . 1427–33 . The Journal of Pharmacology and Experimental Therapeutics.