Arachidonate—CoA ligase explained

Arachidonate—CoA ligase
Ec Number:6.2.1.15
Cas Number:82047-87-8
Go Code:0047676

In enzymology, an arachidonate—CoA ligase is an enzyme that catalyzes the chemical reaction

ATP + arachidonate + CoA

\rightleftharpoons

AMP + diphosphate + arachidonoyl-CoA

The 3 substrates of this enzyme are ATP, arachidonate, and CoA, whereas its 3 products are AMP, diphosphate, and arachidonoyl-CoA.

This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. The systematic name of this enzyme class is arachidonate:CoA ligase (AMP-forming). This enzyme is also called arachidonoyl-CoA synthetase.

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