Antipsychotic ester explained

An antipsychotic ester is an ester of an antipsychotic.^[1] They are used clinically as prodrugs to increase fat solubility and thereby prolong duration when antipsychotics are used as depot injectables.

List of clinically used antipsychotic esters

Typical antipsychotics

• Bromperidol decanoate
• Clopentixol decanoate
• Flupentixol decanoate
• Fluphenazine decanoate
• Fluphenazine enanthate
• Haloperidol decanoate
• Oxyprothepin decanoate
• Perphenazine decanoate
• Perphenazine enanthate
• Pipotiazine palmitate
• Pipotiazine undecylenate
• Zuclopentixol acetate
• Zuclopentixol decanoate

Atypical antipsychotics

• Aripiprazole lauroxil
• Paliperidone palmitate

Notes and References

1. Spanarello S, La Ferla T . The pharmacokinetics of long-acting antipsychotic medications . Current Clinical Pharmacology . 9 . 3 . 310–7 . 2014 . 23343447 . 10.2174/15748847113089990051 .