Anticorticotropin Explained

An anticorticotropin, or anticorticotrophin, is a drug which opposes the actions of corticotropin-releasing hormone (CRH) and/or adrenocorticotropic hormone (ACTH) in relation to their stimulatory effects on the adrenal glands, or which otherwise suppresses steroid hormone production in the adrenal glands. It can be said to have anticorticotropic (or anticorticotrophic) effects, and is used to treat Cushing's syndrome, prostate cancer, hyperandrogenism, and other conditions.

Some examples of anticorticotropins include the following:

• Corticosteroids, including glucocorticoids and mineralocorticoids, which exert negative feedback on the hypothalamic–pituitary–adrenal axis to maintain homeostasis^{[1] [2]}
• High-dose estrogens and antiandrogens, which can partially suppress adrenal androgen production^{[3] [4] [5]}
• Certain progestins such as megestrol acetate, medroxyprogesterone acetate, and cyproterone acetate, which likely work via their weak glucocorticoid activity^[6]

Conversely, drugs that stimulate CRH and/or ACTH secretion and/or activate adrenal steroidogenesis, such as antiglucocorticoids like mifepristone, antimineralocorticoids like spironolactone, and adrenal steroidogenesis inhibitors like ketoconazole, metyrapone, mitotane, and aminoglutethimide, have corticotropic or procorticotropic effects.

Anticorticotropins are analogous to antigonadotropins and procorticotropins are analogous to progonadotropins.

See also

• ACTH stimulation test

Notes and References

1. Book: Michael J. Murray. Steven H. Rose. Denise J. Wedel. C. Thomas Wass, Barry A Harrison, Jeff T Mueller, Terence L Trentman. Faust's Anesthesiology Review E-Book: Expert Consult. 10 March 2014. Elsevier Health Sciences. 978-1-4377-0367-2. 554–.
2. Book: Sai-Ching Jim Yeung. Yeung. Internal Medical Care of Cancer Patients. March 2007. PMPH-USA. 978-1-55009-312-4. 699–.
3. Book: Michael Oettel. Ekkehard Schillinger. Estrogens and Antiestrogens II: Pharmacology and Clinical Application of Estrogens and Antiestrogen. 6 December 2012. Springer Science & Business Media. 978-3-642-60107-1. 543.
4. Book: Andrew N. Margioris. George P. Chrousos. Adrenal Disorders. 20 April 2001. Springer Science & Business Media. 978-1-59259-101-5. 84–.
5. Polderman KH, Gooren LJ, van der Veen EA . Effects of gonadal androgens and oestrogens on adrenal androgen levels . Clin. Endocrinol. (Oxf) . 43 . 4 . 415–21 . October 1995 . 7586614 . 10.1111/j.1365-2265.1995.tb02611.x . 6815423 .
6. Book: Philip W. Harvey. Adrenal in Toxicology: Target Organ and Modulator of Toxicity. 28 March 1996. CRC Press. 978-0-7484-0330-1. 284–.