Anti-Scl-70 antibodies explained

Anti-Scl-70 (also called anti-topoisomerase I after the type I topoisomerase target^[1]) is an anti-topoisomerase antibody-type of anti-nuclear autoantibodies, seen mainly in diffuse systemic scleroderma (with a sensitivity of 28–70%), but is also seen in 10–18% of cases of the more limited form of systemic scleroderma called CREST syndrome.^[2] Anti Scl-70 antibodies are associated with more severe scleroderma disease.^[3]

The etymology of scl-70 consists of an abbreviation of scleroderma and a 70 kD extractable immunoreactive fragment that can be obtained from the otherwise larger (100–105 kD) target topoisomerase antigen (called the SCL-70 Antigen) of the antibodies.^[4]

Notes and References

1. Guldner HH, Szostecki C, Vosberg HP, Lakomek HJ, Penner E, Bautz FA . Scl 70 autoantibodies from scleroderma patients recognize a 95 kDa protein identified as DNA topoisomerase I . Chromosoma . 94 . 2 . 132–8 . 1986 . 2428564 . 10.1007/BF00286991 .
2. Table 5-9 in: Book: Mitchell, Richard Sheppard . Kumar, Vinay . Abbas, Abul K. . Fausto, Nelson . Robbins Basic Pathology. Saunders . Philadelphia . 2007. 1-4160-2973-7 . 8th edition.
3. de Rooij DJ, Van de Putte LB, Habets WJ, Van Venrooij WJ . Marker antibodies in scleroderma and polymyositis: clinical associations . Clin. Rheumatol. . 8 . 2 . 231–7 . 1989 . 2547546 . 10.1007/BF02030079 .
4. http://www.immunovision.com/products/product-10-12-2004_10-18-23.html Product Name: SCL-70 Antigen