Anthrax lethal factor endopeptidase explained

Anthrax lethal factor endopeptidase
Ec Number:	3.4.24.83
Cas Number:	477950-41-7

Anthrax lethal factor endopeptidase (lethal toxin) is an enzyme that catalyzes the hydrolysis of mitogen-activated protein kinase kinases. This enzyme is a component of the lethal factor produced by the bacterium Bacillus anthracis. The preferred cleavage site can be denoted by BBBBxHxH, in which B denotes a basic amino acid Arg or Lys, H denotes a hydrophobic amino acid, and x is any amino acid.^[1]

Notes and References

1. Pannifer AD, Wong TY, Schwarzenbacher R, Renatus M, Petosa C, Bienkowska J, Lacy DB, Collier RJ, Park S, Leppla SH, Hanna P, Liddington RC . Crystal structure of the anthrax lethal factor . Nature . 414 . 6860 . 229–33 . November 2001 . 11700563 . 10.1038/n35101998 . 2027.42/62772 . 9212908 . free .