Annexin A3 Explained

Annexin A3 is a protein that in humans is encoded by the ANXA3 gene.^{[1] [2]}

It is abnormally expressed in fetuses of both IVF and ICSI, which may contribute to the increase risk of birth defects in these ART.^[3]

This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions in the inhibition of phospholipase A2 and cleavage of inositol 1,2-cyclic phosphate to form inositol 1-phosphate. This protein may also play a role in anti-coagulation.^[2]

Further reading

• Ernst JD, Hoye E, Blackwood RA, Jaye D . Purification and characterization of an abundant cytosolic protein from human neutrophils that promotes Ca2(+)-dependent aggregation of isolated specific granules. . J. Clin. Invest. . 85 . 4 . 1065–71 . 1990 . 2138632 . 10.1172/JCI114537 . 296536 .
• Ross TS, Tait JF, Majerus PW . Identity of inositol 1,2-cyclic phosphate 2-phosphohydrolase with lipocortin III. . Science . 248 . 4955 . 605–7 . 1990 . 2159184 . 10.1126/science.2159184 . 1990Sci...248..605R .
• Pepinsky RB, Tizard R, Mattaliano RJ . Five distinct calcium and phospholipid binding proteins share homology with lipocortin I. . J. Biol. Chem. . 263 . 22 . 10799–811 . 1988 . 10.1016/S0021-9258(18)38041-4 . 2968983 . etal. free .
• Tait JF, Sakata M, McMullen BA . Placental anticoagulant proteins: isolation and comparative characterization four members of the lipocortin family. . Biochemistry . 27 . 17 . 6268–76 . 1989 . 2975506 . 10.1021/bi00417a011 . etal.
• Tait JF, Smith C, Xu L, Cookson BT . Structure and polymorphisms of the human annexin III (ANX3) gene. . Genomics . 18 . 1 . 79–86 . 1994 . 8276419 . 10.1006/geno.1993.1428 .
• Sekar MC, Sambandam V, Grizzle WE, McDonald JM . Dissociation of cyclic inositol phosphohydrolase activity from annexin III. . J. Biol. Chem. . 271 . 14 . 8295–9 . 1996 . 8626524 . 10.1074/jbc.271.14.8295 . free .
• Favier-Perron B, Lewit-Bentley A, Russo-Marie F . The high-resolution crystal structure of human annexin III shows subtle differences with annexin V. . Biochemistry . 35 . 6 . 1740–4 . 1996 . 8639653 . 10.1021/bi952092o .
• Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery. . Genome Res. . 6 . 9 . 791–806 . 1997 . 8889548 . 10.1101/gr.6.9.791 . free .
• Cargill M, Altshuler D, Ireland J . Characterization of single-nucleotide polymorphisms in coding regions of human genes. . Nat. Genet. . 22 . 3 . 231–8 . 1999 . 10391209 . 10.1038/10290 . 195213008 . etal.
• Bödeker H, Keim V, Fiedler F . PAP I interacts with itself, PAP II, PAP III, and lithostathine/regIalpha. . Mol. Cell Biol. Res. Commun. . 2 . 3 . 150–4 . 2000 . 10662590 . 10.1006/mcbr.1999.0166 . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Gevaert K, Goethals M, Martens L . Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. . Nat. Biotechnol. . 21 . 5 . 566–9 . 2004 . 12665801 . 10.1038/nbt810 . 23783563 . etal.
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Bruneel A, Labas V, Mailloux A . Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis. . Proteomics . 5 . 15 . 3876–84 . 2006 . 16130169 . 10.1002/pmic.200401239 . 26007149 . etal.
• Stelzl U, Worm U, Lalowski M . A human protein-protein interaction network: a resource for annotating the proteome. . Cell . 122 . 6 . 957–68 . 2005 . 16169070 . 10.1016/j.cell.2005.08.029 . etal. 11858/00-001M-0000-0010-8592-0 . 8235923 . free .
• Park JE, Lee DH, Lee JA . Annexin A3 is a potential angiogenic mediator. . Biochem. Biophys. Res. Commun. . 337 . 4 . 1283–7 . 2005 . 16236264 . 10.1016/j.bbrc.2005.10.004 . etal.

Notes and References

1. Tait JF, Frankenberry DA, Miao CH, Killary AM, Adler DA, Disteche CM . Chromosomal localization of the human annexin III (ANX3) gene . Genomics . 10 . 2 . 441–8 . Aug 1991 . 1830024 . 10.1016/0888-7543(91)90330-H .
2. Web site: Entrez Gene: ANXA3 annexin A3.
3. Zhang Y, Zhang YL, Feng C . Comparative proteomic analysis of human placenta derived from assisted reproductive technology . Proteomics . 8. 20. 4344–56. September 2008 . 18792929 . 10.1002/pmic.200800294 . 206362532 . etal.