Anileridine Explained

Anileridine (trade name: Leritine) is a synthetic analgesic drug[1] and is a member of the piperidine class of analgesic agents[2] developed by Merck & Co. in the 1950s.[3] It differs from pethidine (meperidine) in that the N-methyl group of meperidine is replaced by an N-aminophenethyl group, which increases its analgesic activity.

Anileridine is no longer manufactured in the US or Canada.[4] Anileridine is in Schedule II of the Controlled Substances Act 1970 of the United States as ACSCN 9020 with a zero aggregate manufacturing quota as of 2014. The free base conversion ratio for salts includes 0.83 for the dihydrochloride and 0.73 for the phosphate.[5] It is also under international control per UN treaties.

Administration

As tablets or injection.[6]

Pharmacokinetics

Anileridine usually takes effect within 15 minutes of either oral or intravenous administration, and lasts 2–3 hours.[7] It is mostly metabolized by the liver.

See also

Notes and References

  1. Orahovats PD, Lehman EG, Chapin EW . Pharmacology of ethyl-1-(4-aminophenethyl)-4-phenylisonipecotate, anileridine, a new potent synthetic analgesic . The Journal of Pharmacology and Experimental Therapeutics . 119 . 1 . 26–34 . January 1957 . 13417056 .
  2. Stage JT . Anileridine as an anesthetic agent . The Journal of the Florida Medical Association. Florida Medical Association . 44 . 2 . 143–5 . August 1957 . 13449255 .
  3. US . 2897204 . Frank A Cutler Jr FA, Chemerda JM . Substituted piperidines and methods for making same . Merck and Co Inc . 28 July 1959 .
  4. Web site: Discontinued Prescription Drug Products. Canadian Pharmacists' Association. 28 July 2008. https://web.archive.org/web/20080919134815/http://www.pharmacists.ca/content/hcp/tools/drugnews/discontinued.htm. 19 September 2008. dead.
  5. Web site: Federal Register Notices: Quotas - 2014 . 25 August 2014 . Diversion Control Division, Drug Enforcement Agency . U.S. Department of Justice . 26 February 2016 . 4 March 2016 . https://web.archive.org/web/20160304053357/http://www.deadiversion.usdoj.gov/fed_regs/quotas/2014/fr0825.htm . dead .
  6. Web site: Pharmaceutical Information - LERITINE . RxMed . 16 June 2010 .
  7. Web site: Anileridine Consumer Information . MedicineNet . 28 July 2008 . https://web.archive.org/web/20120328085403/http://www.medicinenet.com/anileridine-oral_tablet/article.htm . 28 March 2012 .

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