Anhydro-N-acetylmuramic acid kinase explained
| Anhydro-N-acetylmuramic acid kinase |
| Ec Number: | 2.7.1.170 |
Anhydro-N-acetylmuramic acid kinase (anhMurNAc kinase, AnmK) is an enzyme with systematic name ATP:1,6-anhydro-N-acetyl-beta-muramate 6-phosphotransferase.[1] [2] [3] This enzyme catalyses the following chemical reaction
ATP + 1,6-anhydro-N-acetyl-beta-muramate + H2O
ADP + N-acetylmuramate 6-phosphate
This enzyme is required for the use of anhydro-N-acetylmuramic acid in Pseudomonadota.
Notes and References
- Uehara T, Suefuji K, Valbuena N, Meehan B, Donegan M, Park JT . Recycling of the anhydro-N-acetylmuramic acid derived from cell wall murein involves a two-step conversion to N-acetylglucosamine-phosphate . Journal of Bacteriology . 187 . 11 . 3643–9 . June 2005 . 15901686 . 1112033 . 10.1128/jb.187.11.3643-3649.2005 .
- Uehara T, Suefuji K, Jaeger T, Mayer C, Park JT . MurQ Etherase is required by Escherichia coli in order to metabolize anhydro-N-acetylmuramic acid obtained either from the environment or from its own cell wall . Journal of Bacteriology . 188 . 4 . 1660–2 . February 2006 . 16452451 . 1367226 . 10.1128/jb.188.4.1660-1662.2006 .
- Bacik JP, Whitworth GE, Stubbs KA, Yadav AK, Martin DR, Bailey-Elkin BA, Vocadlo DJ, Mark BL . Molecular basis of 1,6-anhydro bond cleavage and phosphoryl transfer by Pseudomonas aeruginosa 1,6-anhydro-N-acetylmuramic acid kinase . The Journal of Biological Chemistry . 286 . 14 . 12283–91 . April 2011 . 21288904 . 3069431 . 10.1074/jbc.m110.198317 . free .
