Androgen-dependent condition explained

An androgen-dependent condition, disease, disorder, or syndrome, is a medical condition that is, in part or full, dependent on, or is sensitive to, the presence of androgenic activity in the body.

Known androgen-dependent conditions include acne,^[1] seborrhea,^{[2] [3] [4]} androgenic alopecia,^[5] hirsutism,^[6] hidradenitis suppurativa,^[7] precocious puberty in boys,^[8] hypersexuality,^[9] paraphilias,^[10] benign prostatic hyperplasia (BPH),^[11] prostate cancer,^[12] and hyperandrogenism in women such as in polycystic ovary syndrome (PCOS), congenital adrenal hyperplasia (CAH), and androgen-secreting tumors (gonadal or adrenal tumor).^{[13] [14]}

Such conditions may be treated with drugs with antiandrogen actions, including androgen receptor antagonists such as cyproterone acetate, spironolactone, and bicalutamide, 5α-reductase inhibitors such as finasteride and dutasteride, CYP17A1 inhibitors such as abiraterone acetate, gonadotropin-releasing hormone (GnRH) analogues such as leuprorelin and cetrorelix, and/or other antigonadotropins such as megestrol acetate and medroxyprogesterone acetate.^{[15] [16]}

See also

• Androgen deprivation therapy
• Androgen insensitivity syndrome
• Estrogen-dependent condition
• Spinal bulbar muscular atrophy

Further reading

• Shukla. G. C.. Plaga. A. R.. Shankar. E.. Gupta. S.. Androgen receptor-related diseases: what do we know?. Andrology. 2016. 366–381. 2047-2919. 10.1111/andr.12167. 4. 3. 26991422. free.

Notes and References

1. Book: Joseph E. Pizzorno. Michael T. Murray. Textbook of Natural Medicine. 2013. Elsevier Health Sciences. 978-1-4377-2333-5. 1157–.
2. Book: Steven B. Hoath. Howard I. Maibach. Neonatal Skin: Structure and Function. 18 April 2003. CRC Press. 978-0-8247-0887-0. 67–.
3. Book: Mariagrazia Stracquadanio. Lilliana Ciotta. Metabolic Aspects of PCOS: Treatment With Insulin Sensitizers. 20 April 2015. Springer International Publishing. 978-3-319-16760-2. 25–.
4. Book: Krishna. Usha R.. Adolescence. 1 March 2000. Orient Blackswan. 978-81-250-1794-3. 124–.
5. Book: Mark G. Lebwohl. Warren R. Heymann. John Berth-Jones. Ian Coulson. Treatment of Skin Disease: Comprehensive Therapeutic Strategies. 19 September 2013. Elsevier Health Sciences UK. 978-0-7020-5236-1. 36–.
6. Book: Wilma F. Bergfeld. A Woman Doctor's Guide to Skin Care: Essential Facts and Information on Keeping Skin Healthy. 22 February 1996. Hyperion. 978-0-7868-8100-0.
7. Book: Sarah Bekaert. Women's Health: A Practical Guide for Healthcare Professionals. 2007. Radcliffe Publishing. 978-1-84619-029-2. 128–.
8. Book: Ora Hirsch Pescovitz. Erica A. Eugster. Pediatric Endocrinology: Mechanisms, Manifestations, and Management. 2004. Lippincott Williams & Wilkins. 978-0-7817-4059-3. 328–.
9. Book: Newsletter. 1986. The Academy.
10. Book: Adrian Raine. Crime and Schizophrenia: Causes and Cures. 2006. Nova Publishers. 978-1-59454-609-9. 290–.
11. Book: Christopher R. Chapple. William D. Steers. Practical Urology: Essential Principles and Practice: Essential Principles and Practice. 10 May 2011. Springer Science & Business Media. 978-1-84882-034-0. 361–.
12. Book: P. J. Bentley. Endocrine Pharmacology: Physiological Basis and Therapeutic Applications. 1980. CUP Archive. 978-0-521-22673-8. 321–.
13. Book: Raphael Rubin. David S. Strayer. Emanuel Rubin . Jay M. McDonald . Rubin's Pathology: Clinicopathologic Foundations of Medicine. 2008. Lippincott Williams & Wilkins. 978-0-7817-9516-6. 816–.
14. Book: Andrea Dunaif. R. Jeffrey Chang. Stephen Franks. Richard S. Legro. Polycystic Ovary Syndrome: Current Controversies, from the Ovary to the Pancreas. 12 January 2008. Springer Science & Business Media. 978-1-59745-108-6. 222–.
15. Book: Kenneth L. Becker. Principles and Practice of Endocrinology and Metabolism. 2001. Lippincott Williams & Wilkins. 978-0-7817-1750-2. 1195–.
16. Book: Annual Reports in Medicinal Chemistry. 3 October 1994. Academic Press. 978-0-08-058373-0. 1994–.