Andrastin A Explained

Andrastin A is a farnesyltransferase inhibitor isolate of Penicillium species including Penicillium albocoremium[1] and Penicillium roqueforti.[2] It has been produced bio-synthetically by porting the relevant gene sequence into Aspergillus oryzae.[3]

See also

Notes and References

  1. 16279417 . Mycol Res . 2005 . 109 . Pt 11 . 1243–1249 . Andrastin A and barceloneic acid metabolites, protein farnesyl transferase inhibitors from Penicillium albocoremium: chemotaxonomic significance and pathological implications . Overy DP, Larsen TO, Dalsgaard PW, Frydenvang K, Phipps R, Munro MH, Christophersen C . 10.1017/S0953756205003734.
  2. Nielsen KF, Dalsgaard PW, Smedsgaard J, Larsen TO . Andrastins A-D, Penicillium roqueforti Metabolites consistently produced in blue-mold-ripened cheese . J. Agric. Food Chem. . 53 . 8 . 2908–13 . April 2005. 15826038 . 10.1021/jf047983u .
  3. Matsuda. Yudai. Awakawa. Takayoshi. Abe. Ikuro. Reconstituted biosynthesis of fungal meroterpenoid andrastin A. Tetrahedron. September 2013. 69. 38. 8199–8204. 10.1016/j.tet.2013.07.029.

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