Analbuminaemia Explained

Analbuminaemia
Synonyms:Congenital analbuminemia
Field:Endocrinology
Symptoms:mild oedema, reduced blood pressure, fatigue.
Onset:Adulthood
Causes:Genetic
Frequency:Approximately one per million

Analbuminaemia or analbuminemia is a rare genetically inherited metabolic defect characterised by an impaired synthesis of serum albumin.[1] Although albumin is the most common serum protein, analbuminaemia is a benign condition.

Signs and symptoms

Analbuminaemia often presents in adulthood, with benign clinical features, such as mild oedema, low blood pressure and fatigue. Some patients may develop more serious symptoms such as lower body lipodystrophy. Severe hypercholesterolemia with increased serum low-density lipoprotein-cholesterol concentration and increased esterified cholesterol are often observed. Free fatty acids and raised apolipoprotein B may occur as well as increased serum high-density lipoprotein-3 and apolipoprotein A-I and A-II levels.[2]

It was shown that these persons have a normal life expectancy without substantial impairments.[3]

Notes and References

  1. Watkins S, Madison J, Galliano M, Minchiotti L, Putnam FW . Analbuminemia: three cases resulting from different point mutations in the albumin gene . Proc. Natl. Acad. Sci. U.S.A. . 91 . 20 . 9417–21 . 1994 . 7937781 . 10.1073/pnas.91.20.9417 . 44823. 1994PNAS...91.9417W . free .
  2. Crook . M . 19 July 2016 . Analbuminaemia: clinical features and associated hypercholesterolaemia. . Annals of Clinical Biochemistry . 53 . 5 . 525–526 . 10.1177/0004563216657841 . free . 27329215 .
  3. Foster BM, Abdollahi A, Henderson GC. Alterations in the Plasma Protein Expression Pattern in Congenital Analbuminemia-A Systematic Review. . Biomolecules . 2023 . 13 . 3 . 407 . 36979342 . 10.3390/biom13030407 . free . 10046341 .