Amphinase Explained
| Amphinase |
| Organism: | Rana pipiens |
| Taxid: | 8404 |
| Symbol: | n/a |
| Pdb: | 2P7S |
| Uniprot: | P85073 |
| Ecnumber: | 3.1.27 |
Amphinase is a ribonuclease enzyme found in the oocytes of the Northern leopard frog (Rana pipiens). Amphinase is a member of the pancreatic ribonuclease protein superfamily and degrades long RNA substrates.[1] Along with ranpirnase, another leopard frog ribonuclease, amphinase has been studied as a potential cancer therapy due to its unusual mechanism of cytotoxicity tested against tumor cells.[2]
Notes and References
- Singh UP, Ardelt W, Saxena SK, Holloway DE, Vidunas E, Lee HS, Saxena A, Shogen K, Acharya KR . Enzymatic and structural characterisation of amphinase, a novel cytotoxic ribonuclease from Rana pipiens oocytes . Journal of Molecular Biology . 371 . 1 . 93–111 . August 2007 . 17560606 . 10.1016/j.jmb.2007.04.071 .
- Ardelt W, Shogen K, Darzynkiewicz Z . Onconase and amphinase, the antitumor ribonucleases from Rana pipiens oocytes . Current Pharmaceutical Biotechnology . 9 . 3 . 215–25 . June 2008 . 18673287 . 2586917 . 10.2174/138920108784567245 .
