Amperozide Explained

Amperozide is an atypical antipsychotic of the diphenylbutylpiperazine class which acts as an antagonist at the 5-HT_2A receptor.^[1] It does not block dopamine receptors as with most antipsychotic drugs,^[2] but does inhibit dopamine release,^{[3] [4]} and alters the firing pattern of dopaminergic neurons.^[5] It was investigated for the treatment of schizophrenia in humans,^[6] but never adopted clinically. Its main use is instead in veterinary medicine, primarily in intensively farmed pigs, for decreasing aggression and stress and thereby increasing feeding and productivity.^{[7] [8] [9]}

Notes and References

1. Svartengren J, Simonsson P . Receptor binding properties of amperozide . Pharmacology & Toxicology . 66 . 8–11 . 2154737 . 10.1111/j.1600-0773.1990.tb01599.x . 1990 . Suppl 1 .
2. Meltzer HY, Zhang Y, Stockmeier CA . Effect of amperozide on rat cortical 5-HT2 and striatal and limbic dopamine D2 receptor occupancy: implications for antipsychotic action . European Journal of Pharmacology . 216 . 1 . 67–71 . May 1992 . 1388121 . 10.1016/0014-2999(92)90210-u .
3. Eriksson E . Amperozide, a putative anti-psychotic drug: uptake inhibition and release of dopamine in vitro in the rat brain . Life Sciences . 47 . 23 . 2111–7 . 1979998 . 10.1016/0024-3205(90)90310-n . 1990 .
4. Yamamoto BK, Meltzer HY . The effect of the atypical antipsychotic drug, amperozide, on carrier-mediated striatal dopamine release measured in vivo . The Journal of Pharmacology and Experimental Therapeutics . 263 . 1 . 180–5 . October 1992 . 1403783 .
5. Grenhoff J, Tung CS, Ugedo L, Svensson TH . Effects of amperozide, a putative antipsychotic drug, on rat midbrain dopamine neurons recorded in vivo . Pharmacology & Toxicology . 66 . 29–33 . 2304893 . 10.1111/j.1600-0773.1990.tb01603.x . 1990 . Suppl 1 .
6. Axelsson R, Nilsson A, Christensson E, Björk A . Effects of amperozide in schizophrenia. An open study of a potent 5-HT2 receptor antagonist . Psychopharmacology . 104 . 3 . 287–92 . 1924636 . 10.1007/bf02246025 . 1991 . 2507927 .
7. Kyriakis SC, Martinsson K, Olsson NG, Bjork A . Thin sow syndrome (TSS): the effect of amperozide . The British Veterinary Journal . 146 . 5 . 463–7 . 2224491 . 10.1016/0007-1935(90)90036-3 . 1990 .
8. Kyriakis SC, Olsson NG, Martinsson K, Björk AK . Observations on the action of amperozide: are there social influences on sow-litter productivity? . Research in Veterinary Science . 51 . 2 . 169–73 . September 1991 . 1788479 . 10.1016/0034-5288(91)90008-C .
9. Papp I, Waller C, Biro O . [Practical experiences in the therapy of postweaning edema disease in piglets] . Berliner und Munchener Tierarztliche Wochenschrift . 109 . 10 . 385–7 . October 1996 . 8999770 .