Phospholipid-translocating ATPase explained
| phospholipid-translocating ATPase |
| Ec Number: | 3.6.3.1 |
| Go Code: | 0004012 |
In enzymology, a phospholipid-translocating ATPase is an enzyme that catalyzes the chemical reaction
ATP + H2O + phospholipid in
ADP + phosphate + phospholipid out
The 3 substrates of this enzyme are ATP, H2O, and phospholipid, whereas its 3 products are ADP, phosphate, and phospholipid.
This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides to catalyse transmembrane movement of substances. The systematic name of this enzyme class is ATP phosphohydrolase (phospholipid-flipping). Other names in common use include Mg2+-ATPase, flippase, and aminophospholipid-transporting ATPase.
References
- Morris MB, Auland ME, Xu YH, Roufogalis BD . 1993 . Characterization of the Mg(2+)-ATPase activity of the human erythrocyte membrane . Biochem. Mol. Biol. Int. . 31 . 823 - 32 . 8136700 . 5 .
- 10.3109/09687689609160582 . Vermeulen WP, Briede JJ, Roelofsen B . 1996 . Manipulation of the phosphatidylethanolamine pool in the human red cell membrane affects its Mg2+-ATPase activity . Mol. Membr. Biol. . 13 . 95 - 102 . 8839453 . 2 .
- Suzuki H, Kamakura M, Morii M, Takeguchi N . 1997 . The phospholipid flippase activity of gastric vesicles . J. Biol. Chem. . 272 . 10429 - 34 . 9099684 . 10.1074/jbc.272.16.10429 . 16 . free .
- Auland ME, Roufogalis BD, Devaux PF, Zachowski A . 1994 . Reconstitution of ATP-dependent aminophospholipid translocation in proteoliposomes . Proc. Natl. Acad. Sci. U.S.A. . 91 . 10938 - 42 . 7971987 . 10.1073/pnas.91.23.10938 . 23 . 45141 . free .
