Aminopeptidase S Explained

Aminopeptidase S
Ec Number:	3.4.11.24

Aminopeptidase S (Mername-AA022 peptidase, SGAP, aminopeptidase (Streptomyces griseus), Streptomyces griseus aminopeptidase, S. griseus AP, double-zinc aminopeptidase) is an enzyme.^{[1] [2] [3] [4] [5]} This enzyme catalyses the following chemical reaction

Release of an N-terminal amino acid with a preference for large hydrophobic amino-terminus residues

This enzyme contains two zinc molecules in its active site and is activated by Ca²⁺.

Notes and References

1. Spungin A, Blumberg S . Streptomyces griseus aminopeptidase is a calcium-activated zinc metalloprotein. Purification and properties of the enzyme . European Journal of Biochemistry . 183 . 2 . 471–7 . August 1989 . 2503378 . 10.1111/j.1432-1033.1989.tb14952.x . free .
2. Ben-Meir D, Spungin A, Ashkenazi R, Blumberg S . Specificity of Streptomyces griseus aminopeptidase and modulation of activity by divalent metal ion binding and substitution . European Journal of Biochemistry . 212 . 1 . 107–12 . February 1993 . 8444149 . 10.1111/j.1432-1033.1993.tb17639.x . free .
3. Arima J, Uesugi Y, Iwabuchi M, Hatanaka T . Study on peptide hydrolysis by aminopeptidases from Streptomyces griseus, Streptomyces septatus and Aeromonas proteolytica . Applied Microbiology and Biotechnology . 70 . 5 . 541–7 . May 2006 . 16080009 . 10.1007/s00253-005-0105-8 . 25238513 .
4. Fundoiano-Hershcovitz Y, Rabinovitch L, Langut Y, Reiland V, Shoham G, Shoham Y . Identification of the catalytic residues in the double-zinc aminopeptidase from Streptomyces griseus . FEBS Letters . 571 . 1–3 . 192–6 . July 2004 . 15280041 . 10.1016/j.febslet.2004.07.001 . 22847360 .
5. Gilboa R, Greenblatt HM, Perach M, Spungin-Bialik A, Lessel U, Wohlfahrt G, Schomburg D, Blumberg S, Shoham G . Interactions of Streptomyces griseus aminopeptidase with a methionine product analogue: a structural study at 1.53 A resolution . Acta Crystallographica Section D . 56 . Pt 5 . 551–8 . May 2000 . 10771423 . 10.1107/s0907444900002420 .