Aminopeptidase I Explained

Aminopeptidase I
Ec Number:	3.4.11.22
Cas Number:	9031-94-1

Aminopeptidase I (aminopeptidase III, aminopeptidase yscI, leucine aminopeptidase IV, yeast aminopeptidase I) is an enzyme.^{[1] [2] [3] [4]} This enzyme catalyses the following chemical reaction

Release of an N-terminal amino acid, preferably a neutral or hydrophobic one, from a polypeptide.

Aminoacyl-arylamides are poor substrates

Notes and References

1. Isolation and properties of a pure yeast polypeptidase . Johnson MJ . J. Biol. Chem. . 1941 . 137 . 2 . 575–586 . 10.1016/S0021-9258(19)56163-4 . free .
2. Metz G, Röhm KH . Yeast aminopeptidase I. Chemical composition and catalytic properties . Biochimica et Biophysica Acta (BBA) - Enzymology . 429 . 3 . 933–49 . May 1976 . 5147 . 10.1016/0005-2744(76)90338-7 .
3. Chang YH, Smith JA . Molecular cloning and sequencing of genomic DNA encoding aminopeptidase I from Saccharomyces cerevisiae . The Journal of Biological Chemistry . 264 . 12 . 6979–83 . April 1989 . 10.1016/S0021-9258(18)83527-X . 2651436 . free .
4. Oda MN, Scott SV, Hefner-Gravink A, Caffarelli AD, Klionsky DJ . Identification of a cytoplasm to vacuole targeting determinant in aminopeptidase I . The Journal of Cell Biology . 132 . 6 . 999–1010 . March 1996 . 8601598 . 2120762 . 10.1083/jcb.132.6.999 .