Aminopeptidase B Explained

Aminopeptidase B
Ec Number:	3.4.11.6
Cas Number:	9073-92-1

Aminopeptidase B (arylamidase II, arginine aminopeptidase, arginyl aminopeptidase, Cl—activated arginine aminopeptidase, cytosol aminopeptidase IV, L-arginine aminopeptidase) is an enzyme.^{[1] [2] [3] [4] [5] [6]} This enzyme catalyses the following chemical reaction

Release of N-terminal Arg and Lys from oligopeptides when P1' is not Pro. Also acts on arylamides of Arg and Lys

This enzyme from mammalian tissues is activated by chloride ions and low concentrations of thiol compounds.

An inhibitor is bestatin (ubenimex).

Notes and References

1. Gainer H, Russell JT, Loh YP . An aminopeptidase activity in bovine pituitary secretory vesicles that cleaves the N-terminal arginine from beta-lipotropin60-65 . FEBS Letters . 175 . 1 . 135–9 . September 1984 . 6434344 . 10.1016/0014-5793(84)80586-4 . free .
2. Belhacene N, Mari B, Rossi B, Auberger P . Characterization and purification of T lymphocyte aminopeptidase B: a putative marker of T cell activation . European Journal of Immunology . 23 . 8 . 1948–55 . August 1993 . 8344358 . 10.1002/eji.1830230833 . 855382 .
3. Cadel S, Pierotti AR, Foulon T, Créminon C, Barré N, Segrétain D, Cohen P . Aminopeptidase-B in the rat testes: isolation, functional properties and cellular localization in the seminiferous tubules . Molecular and Cellular Endocrinology . 110 . 1–2 . 149–60 . April 1995 . 7672445 . 10.1016/0303-7207(95)03529-g . 6951437 .
4. Fukasawa KM, Fukasawa K, Kanai M, Fujii S, Harada M . Molecular cloning and expression of rat liver aminopeptidase B . The Journal of Biological Chemistry . 271 . 48 . 30731–5 . November 1996 . 8940051 . 10.1074/jbc.271.48.30731 . free .
5. Cadel S, Foulon T, Viron A, Balogh A, Midol-Monnet S, Noël N, Cohen P . Aminopeptidase B from the rat testis is a bifunctional enzyme structurally related to leukotriene-A4 hydrolase . Proceedings of the National Academy of Sciences of the United States of America . 94 . 7 . 2963–8 . April 1997 . 9096329 . 20305 . 10.1073/pnas.94.7.2963 . 1997PNAS...94.2963C . free .
6. Orning L, Gierse JK, Fitzpatrick FA . The bifunctional enzyme leukotriene-A4 hydrolase is an arginine aminopeptidase of high efficiency and specificity . The Journal of Biological Chemistry . 269 . 15 . 11269–73 . April 1994 . 10.1016/S0021-9258(19)78120-4 . 8157657 . free .