Aminomuconate-semialdehyde dehydrogenase explained

aminomuconate-semialdehyde dehydrogenase
Ec Number:	1.2.1.32
Cas Number:	37250-95-6
Go Code:	0047102
Width:	270

In enzymology, an aminomuconate-semialdehyde dehydrogenase is an enzyme that catalyzes the chemical reaction

2-aminomuconate 6-semialdehyde + NAD⁺ + H₂O

\rightleftharpoons 2-aminomuconate + NADH + 2 H⁺

The 3 substrates of this enzyme are 2-aminomuconate 6-semialdehyde, NAD⁺, and H₂O, whereas its 3 products are 2-aminomuconate, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. This enzyme participates in 3 metabolic pathways: benzoic acid degradation via hydroxylation, tryptophan metabolism, and the degradation pathway for toluene and xylene.

Nomenclature

The systematic name of this enzyme class is 2-aminomuconate-6-semialdehyde:NAD+ 6-oxidoreductase. Other names in common use include 2-aminomuconate semialdehyde dehydrogenase, 2-hydroxymuconic acid semialdehyde dehydrogenase, 2-hydroxymuconate semialdehyde dehydrogenase, alpha-aminomuconic epsilon-semialdehyde dehydrogenase, alpha-hydroxymuconic epsilon-semialdehyde dehydrogenase, and 2-hydroxymuconic semialdehyde dehydrogenase.

Further reading

• Ichiyama A, Nakamura S, Kawai H, Honjo T, Nishizuka Y, Hayaishi O, Senoh S . Studies on the metabolism of the benzene ring of tryptophan in mammalian tissues. II. enzymic formation of alpha-aminomuconic acid from 3-hydroxyanthranilic acid . The Journal of Biological Chemistry . 240 . 740–9 . February 1965 . 14275130 .